Absorption, Metabolism and Excretion of [14C]-Lasmiditan - Single Oral Dose Administration

Inclusion Criteria:

- Males and females, between 18 and 60 years of age, inclusive, at Screening

- Have a body mass index range of 18.5 to 32.0 kilograms per meter squared (kg/m²),
inclusive, at Screening

- In good health, determined by no clinically significant findings from medical history,
12 lead electrocardiogram (ECG), and vital signs measurements at Screening or Check-in
(Day 1) as determined by the Investigator (or designee)

- Clinical laboratory evaluations (including clinical chemistry panel [fasted at least
10 hours], hematology/complete blood count [CBC], and urinalysis [UA]; within the
reference range for the test laboratory at Screening and Check-in, unless deemed not
clinically significant by the Investigator (or designee)

- Negative test for selected drugs of abuse at Screening (does not include alcohol) and
at Check-in (does include alcohol)

- Negative hepatitis panel (including hepatitis B surface antigen and hepatitis C virus
antibody and negative human immunodeficiency virus (HIV) antibody screens

- Females must be nonpregnant, nonlactating, and either postmenopausal (defined as no
menstrual period for at least 12 months and confirmed by a serum follicle-stimulating
hormone (FSH) level of ≥40 milli-international units (mIU/mL), surgically sterile
(e.g., bilateral oophorectomy, salpingectomy, and/or hysterectomy) for at least 90
days prior to Screening, or must have undergone bilateral tubal ligation and agree to
use effective contraception. For all females, the pregnancy test results must be
negative at Screening and Check-in

- Males will be surgically sterile for at least 90 days prior to Screening or when
sexually-active with female partners of child-bearing potential will agree to use
contraception from Check-in until 90 days following Discharge. Male participants must
also be willing to refrain from donating sperm from Check-in until 90 days following
Discharge

- Able to comprehend and willing to sign an informed consent form (ICF)

- A minimum of 1 to 2 bowel movements per day

Exclusion Criteria:

- Significant history or clinical manifestation of any metabolic, allergic, infectious,
dermatological, hepatic, renal, hematological, pulmonary, cardiovascular,
gastrointestinal, neurological, or psychiatric disorder (as determined by the
Investigator [or designee]) prior to Check-in

- History of significant hypersensitivity, intolerance, or allergy to any drug compound,
food, or other substance, unless approved by the Investigator (or designee) prior to
Check-in

- History of stomach or intestinal surgery or resection that could alter absorption or
excretion of orally administered drugs prior to Check-in, except that cholecystectomy,
appendectomy, and hernia repair will be allowed if it was not associated with
complications

- History or presence of an abnormal ECG that, in the Investigator's (or designee's)
opinion, is clinically significant at Screening or Check-in

- History of orthostatic hypotension with or without syncope

- A sustained seated systolic blood pressure >150 millimeters of mercury (mmHg) or <90
mmHg or a diastolic blood pressure >90 mmHg or <50 mmHg at Screening or Check in.
Blood pressure may be retested twice at intervals of 5 minutes. The out of range blood
pressure values will be considered sustained if either the systolic or diastolic blood
pressures are outside the stated limits after these 3 assessments

- History of alcoholism or drug addiction within 1 year prior to Check-in

- Use of any tobacco- or nicotine-containing products (including but not limited to
cigarettes, e-cigarettes, pipes, cigars, chewing tobacco, nicotine patches, nicotine
lozenges, or nicotine gum) within 6 months prior to Check-in, or positive cotinine
screen at Screening or Check-in

- Participation in more than 1 other radiolabeled investigational study drug trial
within 12 months prior to Check-in. The previous radiolabeled study drug must have
been received more than 6 months prior to Check-in for this study and the total
exposure from this study and the previous study will be within the recommended levels
considered safe, per United States (US) Title 21 Code of Federal Regulations (CFR)
361.1 (e.g., less than 5,000 millirem [mrem] whole body annual exposure)

- Exposure to significant radiation (e.g., serial x-ray or computed tomography scans,
barium meal, current employment in a job requiring radiation exposure monitoring)
within 12 months prior to Check-in

- Participation in any other investigational study drug trial in which receipt of an
investigational study drug occurred within 5 half-lives (if known) or 30 days prior to
Check-in, whichever is longer

- Use of any prescription medications/products within 14 days prior to Check-in, unless
deemed acceptable by the Investigator (or designee)

- Use of any over-the-counter, nonprescription preparations (including vitamins,
minerals, and phytotherapeutic/herbal/plant-derived preparations) within 7 days prior
to Check-in, unless deemed acceptable by the Investigator (or designee)

- Poor peripheral venous access prior to Check-in

- Donation of whole blood from 56 days prior to Screening through Discharge, inclusive,
or of plasma from 30 days prior to Screening through Discharge, inclusive

- Receipt of blood products within 2 months prior to Check-in

- Participant is at imminent risk of suicide (positive response to question 4 or 5 on
the baseline Columbia-Suicide Severity Rating Scale (C-SSRS) or had a suicide attempt
within 6 months prior to Screening

- Any acute or chronic condition that, in the opinion of the Investigator (or designee),
would limit the particpant's ability to complete or participate in this clinical study

- Any other unspecified reason that, in the opinion of the Investigator (or designee) or
Sponsor, makes the participant unsuitable for enrollment