Anesthetics to Prevent Lung Injury in Cardiac Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/10/2018 |
| Start Date: | June 9, 2017 |
| End Date: | October 2019 |
| Contact: | Brian O'Gara, MD |
| Email: | bpogara@bidmc.harvard.edu |
| Phone: | 617-754-3189 |
The purpose of this study is to investigate whether the use of inhaled anesthetics, compared
to intravenous anesthetics, can affect the amount of lung inflammation and postoperative
respiratory complications seen after cardiac surgery.
to intravenous anesthetics, can affect the amount of lung inflammation and postoperative
respiratory complications seen after cardiac surgery.
Randomized, controlled trial involving 45 adult patients undergoing cardiac surgery with
cardiopulmonary bypass. Patients will be randomized to receive either inhaled anesthesia with
sevoflurane or total intravenous anesthesia (TIVA) with propofol for the maintenance phase of
their cardiac anesthetic. Assessment of lung inflammation will take place using fiberoptic
bronchoscopic sampling of lung fluid as well as serum collection before and after exposure to
cardiopulmonary bypass, and the incidence of compositive postoperative pulmonary
complications will take place in the postoperative period.
cardiopulmonary bypass. Patients will be randomized to receive either inhaled anesthesia with
sevoflurane or total intravenous anesthesia (TIVA) with propofol for the maintenance phase of
their cardiac anesthetic. Assessment of lung inflammation will take place using fiberoptic
bronchoscopic sampling of lung fluid as well as serum collection before and after exposure to
cardiopulmonary bypass, and the incidence of compositive postoperative pulmonary
complications will take place in the postoperative period.
Inclusion Criteria:
- Adult patients (age 18+)
- Undergoing cardiac surgery with cardiopulmonary bypass
Exclusion Criteria:
- Emergency surgery
- History of severe COPD, emphysema, or ILD
- Recent (<2wk) or current use of systemic glucocorticoids
- Prior history of pneumothorax
- Allergy/contraindication to intravenous anesthetics
- Personal or family history of malignant hyperthermia or high risk for malignant
hyperthermia
We found this trial at
1
site
330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Phone: 617-754-3189
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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