Evaluating MMPs in Burns

This is an observational pilot study of patients treated at UF Health Shands Burn Center
adult service. This is a study to determine the predictive value of quantifying
concentrations of specific MMPs. Coupling this with a specialized collection sample
collection system and a calibrated fluorimetry allows for the rapid assessment of MMP
concentrations. This assay has been validated as a predictor of failed wound healing in a
published clinical study involving chronic open wounds.

Inclusion Criteria:

- 18 years of age or older

- Admitted with acute burns injuries (flame, contact or scald) requiring at least one
surgical excision and grafting operation will be considered for inclusion

- Burn injury less than one week old

Exclusion Criteria:

- Electrical, chemical or cold-induced burn injury

- Total body surface area burn >50 %

- Pre injury diagnosis of chronic renal insufficiency, liver failure, refusal to accept
blood transfusion or withdrawal of care within three days of admission will also be
exclusion criteria

- Patients not expected to survive

- Patients presenting with re-injury to previously burned and treated areas.

- Patients who present after receiving burn excision surgery out an outside facility for
the current acute injury