Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery

PRIMARY OBJECTIVES:

I. To determine the anti-tumor activity of lenvatinib (overall response rate; [ORR]) in
patients with metastatic or advanced unresectable pheochromocytomas and paragangliomas.

SECONDARY OBJECTIVES:

I. To determine progression-free survival (PFS). II. To determine overall survival (OS). III.
To determine duration of tumor response. IV. To determine safety and tolerability of
lenvatinib. V. To assess patient reported quality of life using EuroQol Five-Dimensional Five
Level Scale Questionnaire (EQ-5D-5L) and Functional Assessment of Cancer Therapy-General
(FACT-G).

TERTIARY OBJECTIVES:

I. For patients with secretory tumors, to examine changes in plasma metanephrine levels and
urinary catecholamine and/or metanephrine levels.

II. For patients with secretory tumors, to examine whether lenvatinib-induced changes in
plasma metanephrines and urinary catecholamine and/or metanephrine levels during the first
cycle of treatment may be associated with objective tumor response.

III. To examine associations between tumor response and somatic mutational status in archived
tumors, or germline mutational status (presence of SDHD, SDHB, RET, VHL, neurofibromatosis
type-1).

OUTLINE:

Patients receive lenvatinib orally (PO) once daily (QD) on days 1-28. Courses repeat every 28
days for up to 5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 or 6 months for up to 5
years.

Inclusion Criteria:

- Histologically or cytologically confirmed malignant secretory or non-secretory
pheochromocytoma or paraganglioma that is unresectable and deemed inappropriate for
alternative local regional therapeutic approaches

- Measurable disease

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2

- Life expectancy > 24 weeks

- Absolute neutrophil count (ANC) >= 1500/mm^3

- White blood cell (WBC) count >= 3,000/mm^3

- Platelet count >= 100,000/mm^3

- Hemoglobin >= 9.0 g/dL (5.6 mmol/L); NOTE: transfusions are not allowed =< 7 days
prior to registration

- Total bilirubin =< 1.5 X upper limit of normal (ULN) (or total bilirubin =< 3.0 X ULN
with direct bilirubin =< 1.5 X ULN in patients with well-documented Gilbert's
Syndrome)

- Aspartate transaminase (AST/serum glutamic oxaloacetic transaminase [SGOT]) =< 2.5 X
ULN

- Creatinine =< 1.5 x ULN

- Urine protein/creatinine ratio =< 1 OR 24-hour urine protein < 1.5 gram

- Negative pregnancy test done =< 7 days prior to registration, for women of
childbearing potential only

- Blood pressure (BP) < 150 mmHg (systolic) and < 90 mmHg (diastolic); initiation or
adjustment of BP medication is permitted prior to registration provided that the
average of three BP readings at a visit prior to registration is < 150/90 mmHg; NOTE:
all patients with secretory pheochromocytoma or paraganglioma are REQUIRED to: 1) be
evaluated in consultation by a hypertension specialist with specific experience in the
management of hypertension in the setting of catecholamine-secreting tumors (usually
an endocrinologist, nephrologist, or a cardiologist), and in the setting of
hormone-associated hypertension) receive alpha- and beta-adrenergic blockade for at
least 7-14 days prior to initiation of lenvatinib; the hypertension specialist of
record for each patient should be committed to closely following the patient during
the clinical study with evaluation by said specialist required at cycle 1 and 2 and
thereafter on an as needed basis

- Provide written informed consent

- Willing to return to enrolling institution for follow-up (during the active monitoring
phase of the study)

- Ability to complete questionnaire(s) by themselves or with assistance

Exclusion Criteria:

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Chemotherapy/systemic therapy, radiotherapy, immunotherapy or surgery =< 21 days prior
to registration or kinase inhibitor therapy =< 14 days prior to registration or
failure to recover from toxicities (to grade 1 or below) from treatment; NOTE:
concurrent therapy with octreotide is allowed providing that tumor progression on this
therapy has been demonstrated; concurrent therapy with bisphosphonates (e.g.
zoledronic acid) or denosumab is also allowed; NOTE: an unlimited number of prior
chemotherapeutic or biologic therapies for malignant pheochromocytoma or paraganglioma
is permitted; this includes prior anti-angiogenesis therapies such as tyrosine kinase
inhibitors

- Active or uncontrolled intercurrent illness including, but not limited to, ongoing or
active infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements

- Receiving any other investigational agent

- Current use of warfarin for any reason; NOTE: if patient can be safely transitioned to
another anticoagulant, they may be eligible provided other criteria are satisfied

- Any of the following:

- Correct QT (QTc) prolongation (defined as a QTc interval >= 500 msecs)

- Left ventricular ejection fraction (LVEF) < institutional lower limits of normal
(LLN)

- Frequent ventricular ectopy

- Evidence of ongoing myocardial ischemia

- Receiving any medications or substances with risk of torsades de pointes; NOTE:
medications or substances with known risk of torsades de pointes are prohibited;
consult pharmacist for review if needed

- Known active and/or untreated brain metastases

- Known severe allergic or other prohibitive reactions to other tyrosine kinase
inhibitors (TKI)

- Prior treatment with lenvatinib

- Any of the following conditions:

- Active peptic ulcer disease

- Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease) or other
gastrointestinal conditions which increase the risk of perforation

- History of new abdominal fistula, gastrointestinal perforation or intra-abdominal
abscess =< 84 days prior to registration; NOTE: enrollment of patients with
chronic/canalized fistulous tracts (present for > 84 days) is allowed

- Serious or non-healing wound, ulcer, or bone fracture

- History of familial QTc prolongation syndrome

- Any of the following conditions =< 6 months prior to registration:

- Cerebrovascular accident (CVA) or transient ischemic attack (TIA)

- Serious or unstable cardiac arrhythmia

- Admission for unstable angina or myocardial infarction

- Cardiac angioplasty or stenting

- Coronary artery bypass graft surgery

- Pulmonary embolism, untreated deep venous thrombosis (DVT) or DVT which has been
treated with therapeutic anticoagulation =< 30 days

- Arterial thrombosis

- Symptomatic peripheral vascular disease

- Other active malignancy =< 2 years prior to registration; EXCEPTIONS: non-melanotic
skin cancer or carcinoma-in-situ of the cervix; NOTE: if there is a history of prior
malignancy, they must not be receiving other specific treatment for their cancer;
NOTE: adjuvant anti-estrogen/hormonal therapy for breast cancer is allowed