Safety and Efficacy Study of Filgotinib, GS-9876 and Tirabrutinib in Adults With Active Sjogren's Syndrome



Status:Active, not recruiting
Conditions:Rheumatology
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - 75
Updated:2/21/2019
Start Date:May 1, 2017
End Date:October 2019

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of Filgotinib, GS-9876 and GS-4059 in Adult Subjects With Active Sjogren's Syndrome

The primary objective of this study is to assess the efficacy of filgotinib, GS-9876, and
tirabrutinib (formerly GS-4059) in adults with active Sjogren's Syndrome (SjS).


Key Inclusion Criteria:

- Diagnosed with SjS according to American European Consensus Group (AECG)
classification

- Active SjS as defined by an ESSDAI ≥ 5

- Seropositivity for antibodies to SjS-associated antigens A and B (anti-SSA or
anti-SSB)

Key Exclusion Criteria:

- Concurrent treatment with any biologic disease modifying antirheumatic drug (bDMARD)
(prior bDMARD treatment allowed with appropriate washout as per study protocol)

Note: Other protocol defined Inclusion/Exclusion criteria may apply.
We found this trial at
35
sites
ClinSearch, LLC
Chattanooga, Tennessee 37421
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Chattanooga, TN
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Clinical Research of West Florida
2147 Northeast Coachman Road
Clearwater, Florida 33765
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Clearwater, FL
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Albuquerque Clinical Trials
Albuquerque, New Mexico
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Albuquerque, NM
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Diagnostic Group Integrated Healthcare System, Pllc
3406 College Street
Beaumont, Texas 77701
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Beaumont, TX
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East Penn Rheumatology Associates, P.C.
Bethlehem, Pennsylvania 18015
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Bethlehem, PA
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Joint and Muscle Research Institute
Charlotte, North Carolina 28204
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Charlotte, NC
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Center for Arthritis and Rheumatic Diseases
Chesapeake, Virginia 23320
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Chesapeake, VA
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Medvin Clinical Research
Covina, California 91723
Phone: 626-869-5730
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Covina, CA
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Omega Research Consultants LLC
Debary, Florida
Phone: 386-668-4202
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from
Debary, FL
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Denver Arthritis Clinic
Denver, Colorado 80230
Phone: 303-394-2828
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Denver, CO
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Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
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Duncansville, PA
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Centrum Kliniczno-Badawcze
Elbl?g, 82300
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Elbl?g,
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Center for Arthritis and Osteoporosis
Elizabethtown, Kentucky 42701
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Elizabethtown, KY
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Center for Rheumatology, Immunology and Arthritis
Fort Lauderdale, Florida 33334
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Fort Lauderdale, FL
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Accurate Clinical Research
Houston, Texas
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Houston, TX
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June D.O. PC
Lansing, Michigan 48910
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Lansing, MI
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North Georgia Rheumatology Group
Lawrenceville, Georgia 30046
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Lawrenceville, GA
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Wasatch Peak Family Practice
1580 Antelope Drive
Layton, Utah 84041
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Layton, UT
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Cape Fear Arthritis Care PLLC
1003 Olde Waterford Way
Leland, North Carolina 28451
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Leland, NC
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Physician Research Collaboration
Lincoln, Nebraska 68512
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Lincoln, NE
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Ramesh C. Gupta, M.D.
Memphis, Tennessee 38119
Phone: 901-681-9670
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Memphis, TN
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AARR Arizona Arthritis & Rheumatology Research
Mesa, Arizona 85202
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Mesa, AZ
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Southwest Rheumatology Research LLC
Mesquite, Texas 75150
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Mesquite, TX
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Suncoast Clinical Research, Inc.
New Port Richey, Florida 34652
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New Port Richey, FL
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AARR Arizona Arthritis & Rheumatology Research
4550 East Bell Road
Phoenix, Arizona 85032
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Phoenix, AZ
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Trinity Universal Research Associates, Inc.
Plano, Texas 75024
Phone: 214-726-6721
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Plano, TX
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IRIS Research and Development
Plantation, Florida
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Plantation, FL
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Clayton Medical Associates, P.C.
6400 Clayton Road
Saint Louis, Missouri 63117
Phone: 314-646-0688
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Saint Louis, MO
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Pmg Research Of Salisbury
Salisbury, North Carolina 28144
Phone: 704-647-9913
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Salisbury, NC
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Arthritis Northwest
Spokane, Washington 99204
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Spokane, WA
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Springfield Clinic
Springfield, Illinois 62703
Phone: 217-528-7541
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Springfield, IL
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North Mississippi Medical Clinics, Inc. - Clinical Research
Tupelo, Mississippi 38801
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Tupelo, MS
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Inland Rheumatology Clinical Trials, Inc.
Upland, California 91786
Phone: 909-296-8763
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Upland, CA
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Arthritis & Osteoporosis Clinic
Waco, Texas 76708
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Waco, TX
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Clinical Research Center of Reading, LLC
Wyomissing, Pennsylvania 19610
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Wyomissing, PA
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