Safety and Efficacy Study of Filgotinib, GS-9876 and Tirabrutinib in Adults With Active Sjogren's Syndrome
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Rheumatology |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 2/21/2019 |
| Start Date: | May 1, 2017 |
| End Date: | October 2019 |
A Randomized, Phase 2, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of Filgotinib, GS-9876 and GS-4059 in Adult Subjects With Active Sjogren's Syndrome
The primary objective of this study is to assess the efficacy of filgotinib, GS-9876, and
tirabrutinib (formerly GS-4059) in adults with active Sjogren's Syndrome (SjS).
tirabrutinib (formerly GS-4059) in adults with active Sjogren's Syndrome (SjS).
Key Inclusion Criteria:
- Diagnosed with SjS according to American European Consensus Group (AECG)
classification
- Active SjS as defined by an ESSDAI ≥ 5
- Seropositivity for antibodies to SjS-associated antigens A and B (anti-SSA or
anti-SSB)
Key Exclusion Criteria:
- Concurrent treatment with any biologic disease modifying antirheumatic drug (bDMARD)
(prior bDMARD treatment allowed with appropriate washout as per study protocol)
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
We found this trial at
35
sites
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