This Study Tests a New Medicine Called BI 685509 in Patients That Have Kidney Problems Because of Diabetes. The Study Tests How BI 685509 is Taken up in the Body and How Well it is Tolerated (Multiple Rising Doses)

Inclusion Criteria:

- Signed and dated written informed consent in accordance with ICH-GCP and local
legislation prior to admission to the trial

- Male or postmenopausal (last menstruation ≥ 2 years ago) patients, or female patients
who are sterilized by either hysterectomy, bilateral salpingectomy and/or bilateral
oophorectomy. Male patients with partners of child-bearing potential must be willing
to use condoms from the time of the first intake of study drug until follow-up.

- eGFR (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula) ≥ 20 and <
75 ml/min/1.73 m2 at Visit 1 measured by the central laboratory and no planned start
of renal replacement therapy during the trial

- UACR ≥ 200 and <3500 mg/g in spot urine (midstream urine sample) at Visit 1 measured
by the central laboratory

- Treatment with either ACEi or ARB, stable dose since ≥ 4 weeks before Visit 1 with no
planned change of the therapy

- Patients with type 1 or type 2 diabetes mellitus, diagnosed before informed consent
and treated with insulin, glucagon-like peptide (GLP) 1 agonists and/or oral
antidiabetic medication. Treatment should have been unchanged (investigator's
judgment) within 4 weeks before Visit 1 and until randomisation

- Glycated Haemoglobin (HbA1c) < 10.0% at Visit 1 measured by the central laboratory

- Seated Systolic Blood Pressure (SBP) ≥ 110 and ≤ 180 mmHg and Diastolic Blood Pressure
(DBP) ≥ 70 and ≤ 110 mmHg at Visit 1

- Age at screening ≥ 18 years for male and permanently sterilized female patients and ≥
45 years for postmenopausal female patients

- Body Mass Index (BMI) ≥ 18.5 and < 45 kg/m2

- Successful ABPM reading before randomisation, upper arm circumference within the
circumference level of the cuff size of either ABPM and/or BP measurement device used
in the study

Exclusion Criteria:

- Treatment with SGLT2 inhibitors and/or phosphodiesterase inhibitors, nitrates or
riociguat, from screening (Visit 1) or within 5 half-lives before randomisation
whatever is earlier.

- Any laboratory value more than 3 times above upper limit of normal (ULN) at screening
(Visit 1) or any other laboratory value outside the reference range and clinically
relevant (for safe participation) in the investigator judgment

- Confirmed non-diabetic renal disease in the opinion of investigator

- Any other medical condition that in the investigator's opinion poses a safety risk for
the patient or may interfere with the study objectives including

- symptomatic heart failure (NYHA III/IV),

- known history of tachycardia and/or atrial fibrillation

- clinically relevant arrhythmias

- coronary heart disease not compensated by medical treatment (supine pulse rate
>70 beats per minute, existing angina pectoris)

- <6 months after myocardial infarction.

- Medical history of cancer or treatment for cancer in the last two years prior to Visit
1 (except appropriately treated basal cell carcinoma of the skin, in situ carcinoma of
uterine cervix, and prostatic cancer of low grade [T1 or T2] is exempted)

- Surgery or trauma with significant blood loss (investigator's judgement) within the
last 3 months prior to informed consent or significant blood donation (investigator's
judgement) within four weeks prior to first administration of study medication or
planned during the trial

- Previous randomization in this trial

- Currently enrolled in another investigational device or drug study, i.e., less than 30
days since ending another investigational device or drug study(s), or receiving other
investigational treatment(s)

- Chronic alcohol or drug abuse or any condition that, in the investigator's opinion,
makes them an unreliable study subject or unlikely to complete the trial

- Women of childbearing potential

- Further exclusion criteria apply