Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 60 - 80 |
| Updated: | 8/24/2018 |
| Start Date: | September 2014 |
| End Date: | October 2018 |
Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk
for cognitive decline and dementia, with combinations of non-pharmacological interventions
providing greatest promise for impacting cognitive aging. This, paired with limited cognitive
benefits from pharmacological interventions in dementia, has shifted focus to
non-pharmacological interventions administered earlier in the disease course. This
application, therefore, proposes a randomized controlled trial (RCT; 12-week active
intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided
progressive increases in weekly step counts), computer-based cognitive training program
(Brain HQ, Posit Science), and combination of the exercise and cognitive program, on
cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults
with mild cognitive impairment (MCI).
for cognitive decline and dementia, with combinations of non-pharmacological interventions
providing greatest promise for impacting cognitive aging. This, paired with limited cognitive
benefits from pharmacological interventions in dementia, has shifted focus to
non-pharmacological interventions administered earlier in the disease course. This
application, therefore, proposes a randomized controlled trial (RCT; 12-week active
intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided
progressive increases in weekly step counts), computer-based cognitive training program
(Brain HQ, Posit Science), and combination of the exercise and cognitive program, on
cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults
with mild cognitive impairment (MCI).
Inclusion Criteria:
- MCI diagnosis (can be self referral, will determine eligibility at baseline)
Exclusion Criteria:
- Dementia diagnosis
- Head trauma
- Neuro/psychiatric disorders
- Current substance dependence
- Sensory/mobility deficits
- No more than 1 hour of purposeful, aerobic activity/week
- Currently engaging in any other brain-stimulating computer program (No more than 1
hour a week)
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