Microgravity Effects on Co-cultured Vascular Cells Types
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 21 - 50 |
| Updated: | 2/7/2019 |
| Start Date: | May 26, 2017 |
| End Date: | February 2020 |
| Contact: | Josephine Allen, PhD |
| Email: | jallen@mse.ufl.edu |
| Phone: | 352-846-3328 |
The goal of this study is to assess the affect of ground based microgravity on co-cultured
vascular cell types. Our goal is to better understand the cross-talk between vascular cell
types grown under conditions such as microgravity as is seen in space. In this pilot study,
the investigator proposes to assess changes in cell phenotype and function in microgravity as
compared to normal gravity.
vascular cell types. Our goal is to better understand the cross-talk between vascular cell
types grown under conditions such as microgravity as is seen in space. In this pilot study,
the investigator proposes to assess changes in cell phenotype and function in microgravity as
compared to normal gravity.
This study builds upon previously reported space flight data in GenLab, as well as our own
published data whereby the investigator evaluate the effect of microgravity on the
differentiation and functional potential of circulating stem cells. The goal of this work is
to leverage the powerful genetic analyses done in the SPHINX study and look at the
consequences these changes have on cell-cell communications essential for vascular
homeostasis, for a possible correlation to cardiovascular deconditioning. The application of
this work is targeted at possible "cell based" countermeasures to address the negative
effects of microgravity on the vasculature.
published data whereby the investigator evaluate the effect of microgravity on the
differentiation and functional potential of circulating stem cells. The goal of this work is
to leverage the powerful genetic analyses done in the SPHINX study and look at the
consequences these changes have on cell-cell communications essential for vascular
homeostasis, for a possible correlation to cardiovascular deconditioning. The application of
this work is targeted at possible "cell based" countermeasures to address the negative
effects of microgravity on the vasculature.
Inclusion Criteria:
- Self-reported healthy individuals
- Willingness to have 50mls of whole blood collected
Exclusion Criteria:
- Unwillingness to have blood used in stem cell research
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