A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs ( SELECT-CHOICE )

Inclusion Criteria:

- Diagnosis of rheumatoid arthritis (RA) for >= 3 months.

- Participants have been treated for >= 3 months with >= 1 bDMARD therapy, but continue
to exhibit active RA or had to discontinue due to intolerability or toxicity,
irrespective of treatment duration and have never received abatacept prior to the
first dose of study drug.

- Participants have been receiving csDMARD therapy >= 3 months and on a stable dose for
>= 4 weeks prior to the first dose of study drug. The following csDMARDs are allowed:
methotrexate (MTX), sulfasalazine, hydroxychloroquine, chloroquine, and leflunomide. A
combination of up to two background csDMARDs is allowed except the combination of MTX
and leflunomide.

- Meets the following criteria: >= 6 swollen joints (based on 66 joint counts) and >= 6
tender joints (based on 68 joint counts) at Screening and Baseline Visits and hsCRP >=
3 mg/L at Screening .

Exclusion Criteria:

- Prior exposure to any Janus kinase (JAK) inhibitor (including but not limited to
upadacitinib, tofacitinib, baricitinib and filgotinib).

- Prior exposure to abatacept

- History of any arthritis with onset prior to age 17 years or current diagnosis of
inflammatory joint disease other than RA. Current diagnosis of secondary Sjogren's
Syndrome is permitted

- Laboratory values meeting the following criteria within the Screening period prior to
the first dose of study drug: serum aspartate transaminase > 2 × upper limit of normal
(ULN); serum alanine transaminase > 2 × ULN; estimated glomerular filtration rate by
simplified 4-variable Modification of Diet in Renal Disease formula < 40 milli liter
(mL)/minute/1.73 meter (m)^2; total white blood cell count < 2,500/micro liter (μL);
absolute neutrophil count < 1,500/μL; platelet count < 100,000/μL; absolute lymphocyte
count < 800/μL; and hemoglobin < 10 g/ deciliter (dL).