QP ExCELs: MultiPole Pacing (MPP) Sub-Study

Inclusion Criteria:

- Currently enrolled in the ongoing QP ExCELs study

- Successfully implanted with a BIOTRONIK Ilivia 7 HF-T QP family CRT-D system, or
future-marketed CRT-D system with the MPP feature. Successful implantation is defined
as having at least two LV pacing vectors with a measured pacing threshold of ≤ 5.0 V @
any pulse width (allowing for a minimum 2.5 V safety margin) without phrenic nerve
stimulation at the final programmed pacing output at the time of enrollment into the
MPP sub-study.

- CRT Responder Assessment classification as "Worsened" or "Unchanged"

- Standard continuous biventricular (BiV) pacing from implant until the 6-Month QP
ExCELs follow-up visit. (Implant to 3-Month QP ExCELs follow-up who qualify due to a
HF hospitalization event)

- Able to understand the nature of the sub-study and give informed consent

- Available for an additional follow-up visit specific to the MPP sub-study at the
investigational site

- No evidence of non-compliance to their ongoing commitment in the QP ExCELs study

Exclusion Criteria:

- Have a life expectancy of less than 6 months

- Expected to receive heart transplantation or ventricular assist device within 6 months

- Chronic atrial fibrillation

- Presence of another life-threatening, underlying illness separate from their cardiac
disorder

- Received MPP pacing prior to enrolment into the MPP sub-study