Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes

Carotid endarterectomy (CEA) is a common surgery performed to reduce the risk of stroke in
patients with carotid artery narrowing. Statins, a class of drugs usually used to lower
blood cholesterol, may protect the brain after surgery. Specific statins have been shown to
protect the brain after surgery when compared to others. eCD affects about 25% of patients
undergoing CEA and about 15% of undergoing asymptomatic CEA. It is associated with marked
elevations in tissue markers of cerebral injury and is associated with earlier post-CEA
mortality. This clinically significant, but subtle, cerebral injury is 10 times more common
than stroke and its mechanism appears to be similarly related to regional hypoperfusion and
ischemia. It is imperative to determine in a prospective randomized trial whether
alteration/increase of preoperative statin regimens leads to improved neurologic outcome and
an even lower incidence of stroke and possibly greater survival.

In order to optimally design and conduct such a trial it is critical to: 1) explore the
safety and feasibility of altering statin regimen acutely (approximately 2 weeks) before
CEA, and 2) clearly establish the neuroprotective outcome of an acute alteration in statin
regimen. This would promote a better understanding of statin neuroprotection in humans and
determine the statin treatment that affords the most neuroprotection in patients undergoing
one of the most commonly performed procedures in the US.

Inclusion Criteria:

1. Age ≥ 18 years of age.

2. Patient is currently on atorvastatin or simvastatin or rosuvastatin or statin naïve
(no statins in the last 30 days).

3. The patient has unilateral or bilateral carotid artery stenosis that is considered
severe (carotid artery diameter reduction ≥ 70%) as defined by:

1. Peak systolic velocity of at least 230 cm/s plus at least one of these:

2. End diastolic velocity ≥ 100 cm/s OR

3. CTA showing ≥ 70% stenosis OR

4. MRA showing ≥ 70% stenosis

4. This stenosis has not caused any stroke, transient cerebral ischemia, or other
relevant neurological symptoms in the past.

5. The patient's attending doctor(s) (PMD, cardiologist, vascular/neurosurgeon) AND the
patient have decided to proceed with a CEA to treat the patient's severe carotid
stenosis.

6. The patient has no known circumstance or condition likely to preclude 1 year
follow-up or adherence to the study protocol.

7. The patient is independent in their Activities of Daily Living at baseline.

8. Patient has the ability to provide informed consent.

Exclusion Criteria:

1. Patient has underlying disease other than atherosclerosis (i.e. autoimmune disease,
known active malignancy).

2. Patient has documented dementia or screens out based on abnormal Baseline MoCA (≤25)
and AD8 (≥2).

3. Patient's life expectancy is < 12 months.

4. Patient has advanced renal failure (serum creatinine > 2.5 mg/dL)

5. Patient has evidence of severe congestive heart failure or has history of end-stage
cardiovascular disease (e.g. CHF NYHA Class III or IV or unstable angina).

6. Patient has history of intolerance or allergic reaction to any statins (myotoxicity,
hepatic dysfunction, rash, etc.)

7. Patient has received an investigational drug within 30 days.

8. Patient is pregnant or lactating.

9. Patient is currently taking any of the following which have been shown to interact
with atorvastatin and/or simvastatin and/or rosuvastatin (as per current drug package
inserts):

- Cyclosporine;

- HIV Protease Inhibitors/Antivirals (e.g. rotanavir or plus rotanavir,
tipranavir, lopinavir, boceprevir, saquinovir, darunavir, fosamprenavir,
nelfinavir, efavirenz/tenofobir, atazanavir, simeprevir);

- Hep C Protease Inhibitor/Antivirals (e.g. telapravir);

- Antibiotics (i.e. cobicistat-containing products like Tybost,
rifampin/rifampicin, clarithromycin, telithromycin, erythromycin);

- Anti-fungals (i.e. itraconazole, ketoconazole, posaconazole, voriconazole,
fluconazole); *Gemfibrozil; Other Fenofibrates (e.g. Tricor, fibric acid);

- Niacin > 1g/day or statins in combination with niacin (e.g. Vytorin, Simcor);

- Colchicine;

- Danazol;

- Calcium Channel Blockers: Diltiazem, Varapamil;

- Dronedarone;

- Amiodarone;

- Digoxin;

- Ranolazine;

- Nefazodone;

- Warfarin/Coumadin;

- Lomitapide;

- Grapefruit juice > 1.2 liters/day (40.5 ounces/day).