Kisspeptin Influence on Glucose Homeostasis

Inclusion/Exclusion Criteria:

History:

- stable weight for previous three months (Body Mass Index less than 25),

- no active illicit drug use,

- no history of a medication reaction requiring emergency medical care,

- no difficulty with blood draws.

Physical examination:

• systolic BP < 140 mm Hg, diastolic < 90 mm Hg,

Laboratory studies: (per MGH reference ranges)

- normal hemoglobin, unless hypogonadal then no lower than 0.5 gm/dL below the lower
limit of the reference range for normal women (as men and women with hypogonadism have
lower hemoglobin levels off of treatment)

- hemoglobin A1C < 6.5%

- BUN, creatinine not elevated

- AST, ALT < 3x upper limit of normal

- negative serum pregnancy test (for all women)

Additional Criteria by Study Population

Healthy Women:

- no history of chronic disease, except well controlled thyroid disease,

- no history of diabetes in a first degree relative,

- no use of contraceptive pills, patches or vaginal rings within last 4 weeks.

Men and Women with Impaired Glucose Tolerance (IGT):

- diagnosis of impaired glucose tolerance by oral glucose tolerance test,

- all medical conditions well-controlled.

Men and Women with Hypogonadism

- diagnosis of hypogonadism,

- all other medical conditions well-controlled,

- if applicable, able to undergo appropriate washout from hormone therapy.