A Phase 2 Multicenter Study of Axicabtagene Ciloleucel in Subjects With Relapsed/Refractory Indolent Non-Hodgkin Lymphoma

This study will enroll approximately 160 adult subjects who have relapsed or refractory (r/r)
iNHL to be infused with the study treatment, axicabtagene ciloleucel, to see if their disease
responds to this experimental product and if this product is safe. Axicabtagene ciloleucel is
made from the subjects own white blood cells which are genetically modified and grown to
fight cancer. An objective response rate of 70% is targeted.

All enrolled subjects will be screened for eligibility then will undergo leukapheresis to
collect white blood cells for manufacturing. In preparation for the infusion with
axicabtagene ciloleucel, subjects will undergo conditioning chemotherapy with
cyclophosphamide and fludarabine for 3 days to help the study treatment be effective. After
the product is manufactured and conditioning chemotherapy period is complete, subjects will
be infused with axicabtagene ciloleucel and then monitored in a hospital for a minimum of 7
days. Subjects will be followed by their study doctor for continued monitoring of the safety
and effectiveness of the study treatment for approximately 3 months after receiving treatment
and then will be followed for safety for up to an additional 15 years.

Key Inclusion Criteria:

1. Individual has [follicular lymphoma or marginal zone lymphoma that has progressed
after at least 2 lines of treatment with combination chemoimmunotherapy] (e.g.
R-bendamustine, R-CHOP).

2. Individual has [measurable disease].

3. Individual has no known presence or history of central nervous system (CNS)
involvement by lymphoma.

4. If individual is on conventional systemic therapy or systemic inhibitory/stimulatory
immune checkpoint therapy, individual is able to stop conventional therapy 2 weeks or
5 half-lives, whichever is shorter, or immune checkpoint therapy 3 half-lives prior to
planned leukapheresis.

5. Individual has Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 and
adequate renal, hepatic, pulmonary, and cardiac function

6. Individual is not pregnant or breastfeeding (female individuals only) and is willing
to use birth control from the time of consent through 6 months following chimeric
antigen receptor (CAR) T cell infusion (both male and female individuals).

Key Exclusion Criteria:

1. Transformed follicular lymphoma (FL) or marginal zone lymphoma (MZL)

2. Small lymphocytic lymphoma

3. Histological Grade 3b FL

4. Individual will have undergone autologous transplant within 6 weeks of planned
leukapheresis or has undergone allogeneic transplant.

5. Individual has evidence of involvement of the heart by lymphoma or requirement for
urgent therapy due to ongoing or impending oncologic emergency (e.g. mass effect,
tumor lysis syndrome, etc.)

Note: Other protocol defined Inclusion/Exclusion criteria may apply.