PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer, Cancer, Cancer, Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/10/2019 |
| Start Date: | June 7, 2017 |
| End Date: | June 30, 2020 |
| Contact: | Ryan C Guffey, M.D. |
| Email: | rguffey@wustl.edu |
| Phone: | (314) 286-2883 |
In this double blinded randomized placebo-controlled trial, 160 subjects scheduled for breast
surgery involving the axilla will be administered a multimodal pain regimen including
acetaminophen, dexamethasone, celecoxib, and gabapentin. 80 subjects will also receive a
Pectoral Nerve blocks I and II (PECS I and II block) preoperatively.
surgery involving the axilla will be administered a multimodal pain regimen including
acetaminophen, dexamethasone, celecoxib, and gabapentin. 80 subjects will also receive a
Pectoral Nerve blocks I and II (PECS I and II block) preoperatively.
Inclusion Criteria:
- Scheduled to undergo elective breast cancer surgery involving the axilla or mastectomy
with same day reconstruction at Barnes-Jewish Hospital.
- At least 18 years of age.
- Able to understand and willing to sign an Institutional Review Board (IRB)-approved
written informed consent document.
- Enrollment in the SATISFY-SOS study (WUSTL IRB# 201203088, NCT02032030).
Exclusion Criteria:
- Planned for bilateral axillary surgery.
- Previous surgery other than lumpectomy or sentinel lymph node biopsy on the surgical
breast or axilla.
- Pre-existing pain in the axilla affecting the ability to use extremity for activities
of daily living or requiring medication for treatment.
- Pre-existing liver disease: elevated INR >1.4 or elevated transaminase levels, or
patient medical history of cirrhosis, or liver disease.
- Known contraindications to peripheral nerve block placement.
- Pregnant or breastfeeding.
- History of allergic reactions attributed to compounds of similar chemical or biologic
composition
- Planned additional surgery to the surgical breast or axilla in the next year
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Ryan C Guffey, M.D.
Phone: 314-286-2883
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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