Assessing the Effects of Three Oral Care Regimens

Six month, five visit study of plaque, gingivitis, and tooth whitening with three randomized
intervention groups using FDA marketed and approved products and devices. One hundred fifty
(150) subjects from the patient base of 10 PEARL Network associated dental offices on the
East Coast of the United States will be entered into the clinical research study. This is a
post-marketing comparative effectiveness research study. Having a total of 5 visits over a
six month period. Adverse events and side effects for the products used are being assessed.

Inclusion Criteria

1. Subject males or females 18 to 70 years old (inclusive).

2. Availability for the 6 months duration of the clinical research study

3. Good general health

4. Subject able and willing to follow study procedures and instructions

5. Subject read, understood and signed an informed consent form

6. Subject present with at least 20 natural teeth in the functional dentition (excluding
third molars), including the following natural (uncrowned) teeth for shading: #6, #7,
#8, #9, #10, #11

Exclusion Criteria

Potential subjects must NOT HAVE ANY of the following conditions:

1. Presence of orthodontic bands

2. Presence of partial removable dentures

3. Tumor(s) of the soft or hard tissues of the oral cavity

4. Restorations or crowns that would interfere with color measurements on the following
teeth: #6, #7, #8 , #9, #10 & #11 (upper six front teeth)

5. Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss
of periodontal attachment or alveolar bone)

6. Five or more carious lesions requiring immediate restorative treatment

7. Antibiotic use any time during the one month prior to entry into the study

8. Participation in any other clinical study or test panel within the one month prior to
entry into the study

9. History of allergies to oral care/personal care consumer products or their
ingredients.

10. On any prescription medicines that might interfere with the study outcome

11. An existing medical condition which prohibits eating or drinking for periods up to 4
hours

12. History of alcohol or drug abuse

13. Pregnant or lactating