Dexamethasone and Post-tonsillectomy Pain in Children
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 4 - 17 |
| Updated: | 6/8/2018 |
| Start Date: | June 2016 |
| End Date: | July 2020 |
| Contact: | Olubukola Nafiu, MD |
| Email: | onafiu@med.umich.edu |
| Phone: | 734 936 4280 |
Does Dexamethasone Reduce Postoperative Pain in Pediatric Tonsillectomy Patients?
The investigators will use a prospective randomized, controlled design utilizing a single
preoperative dose of oral dexamethasone or placebo to achieve these specific aims:
- Specific Aim 1: To evaluate the potential for a single preoperative dose of oral
dexamethasone administered the night before surgery to reduce the incidence and severity
of early post tonsillectomy pain (PTP) in children
- Specific Aim 2: To prospectively evaluate differences in early PTP experience between
overweight/obese children and their lean peers.
- Specific Aim 3: To determine whether circulating inflammatory markers are strongly
linked to PTP severity in children and whether they could be potential contributors to
the higher pain experienced by overweight/obese children following Tonsillectomy and or
Adenoidectomy.
preoperative dose of oral dexamethasone or placebo to achieve these specific aims:
- Specific Aim 1: To evaluate the potential for a single preoperative dose of oral
dexamethasone administered the night before surgery to reduce the incidence and severity
of early post tonsillectomy pain (PTP) in children
- Specific Aim 2: To prospectively evaluate differences in early PTP experience between
overweight/obese children and their lean peers.
- Specific Aim 3: To determine whether circulating inflammatory markers are strongly
linked to PTP severity in children and whether they could be potential contributors to
the higher pain experienced by overweight/obese children following Tonsillectomy and or
Adenoidectomy.
(See brief summary as well)
The study will serve as a vehicle for a three-pronged approach (clinical observation,
biological basis and therapeutic intervention) reflects the applicants professional interest
in translational pediatric obesity research If the investigators find that BMI-dependent
disparity exists in Post Tonsillectomy Pain (PTP) and that preoperative down regulation of
inflammatory response with one preoperative dose of corticosteroids reduces PTP, our findings
should ultimately lead to improved postoperative pain management of pediatric PTP especially
in obese children.
The study will serve as a vehicle for a three-pronged approach (clinical observation,
biological basis and therapeutic intervention) reflects the applicants professional interest
in translational pediatric obesity research If the investigators find that BMI-dependent
disparity exists in Post Tonsillectomy Pain (PTP) and that preoperative down regulation of
inflammatory response with one preoperative dose of corticosteroids reduces PTP, our findings
should ultimately lead to improved postoperative pain management of pediatric PTP especially
in obese children.
Inclusion Criteria:
- Scheduled for tonsillectomy and/or adenoidectomy at University of Michigan, C. S. Mott
Children's Hospital
Exclusion Criteria:
- Known hypersensitivity to dexamethasone
- Developmental delay
- Taking chronic analgesics
- Taking chronic systemic steroids
- Treatment with steroids in last 30 days
- Cushings or Prader-Willi or Nephrotic Syndromes
- Diabetes Mellitus
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