Apolipoprotein E (ApoE) and Metabolism
| Status: | Recruiting |
|---|---|
| Conditions: | Cognitive Studies, Cognitive Studies, Healthy Studies |
| Therapuetic Areas: | Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/30/2018 |
| Start Date: | April 24, 2018 |
| End Date: | April 30, 2020 |
| Contact: | Lance Johnson, PhD |
| Email: | Johnson.Lance@uky.edu |
| Phone: | 8593232146 |
APOE, Metabolism and Cognitive Function: An Assessment Via Indirect Calorimetry
Impaired metabolism and the gene apolipoprotein E (ApoE) are independent risk factors for
cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2,
E3, and E4. Some studies suggest that the different versions of apoE have varying effects on
whole body and brain metabolism. The goal of this project is to better understand the
relationship between apoE and metabolism. This will help investigators identify new targets
for the prevention and treatment of cognitive decline and dementia.
cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2,
E3, and E4. Some studies suggest that the different versions of apoE have varying effects on
whole body and brain metabolism. The goal of this project is to better understand the
relationship between apoE and metabolism. This will help investigators identify new targets
for the prevention and treatment of cognitive decline and dementia.
The investigator hopes determine whether a participant's version of ApoE affects their
metabolic rate at rest and during a cognitive challenge. To determine this, the investigator
will measure basal (resting) metabolic rates using a technique called indirect calorimetry
(IC). This is accomplished by wearing a loose-fitting face mask that measures oxygen intake
and carbon dioxide output.
To more accurately measure the amount of carbohydrates, fats and proteins that the body is
metabolizing, participants will be asked to provide two urine samples (one at the beginning,
and one at the end, of the study).
To determine what version of ApoE the participant inherited, the investigator will conduct a
genetic test on DNA isolated from the participant's blood.
metabolic rate at rest and during a cognitive challenge. To determine this, the investigator
will measure basal (resting) metabolic rates using a technique called indirect calorimetry
(IC). This is accomplished by wearing a loose-fitting face mask that measures oxygen intake
and carbon dioxide output.
To more accurately measure the amount of carbohydrates, fats and proteins that the body is
metabolizing, participants will be asked to provide two urine samples (one at the beginning,
and one at the end, of the study).
To determine what version of ApoE the participant inherited, the investigator will conduct a
genetic test on DNA isolated from the participant's blood.
Inclusion Criteria:
- all races/ethnicities
- ages 18-65
- cognitively normal
- good health
Exclusion Criteria:
- pregnant or breastfeeding.
- have a bleeding disorder,
- have a history of stroke, seizures, Parkinson's disease, history of head injury with
loss of consciousness, or other dementing disorder.
- have a history of alcoholism or drug abuse
- have a history of schizophrenia or currently suffer from bipolar disorder or major
depression.
- have vision or hearing loss severe enough to interfere with cognitive testing
We found this trial at
1
site
740 South Limestone Street
Lexington, Kentucky 40536
Lexington, Kentucky 40536
Phone: 859-323-2746
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