Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
Status: | Recruiting |
---|---|
Conditions: | Brain Cancer, Neurology |
Therapuetic Areas: | Neurology, Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 1/31/2019 |
Start Date: | June 14, 2017 |
End Date: | August 31, 2027 |
Contact: | C. Leland Rogers, MD |
Email: | leland.rogers@dignityhealth.org |
Phone: | 602-406-6761 |
Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma
This randomized phase III trial studies how well radiation therapy works compared with
observation in treating patients with newly diagnosed grade II meningioma that has been
completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells
and shrink tumors.
observation in treating patients with newly diagnosed grade II meningioma that has been
completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells
and shrink tumors.
PRIMARY OBJECTIVES:
I. To determine, in terms of progression-free survival (PFS), the extent of clinical benefit
of the addition of adjuvant radiotherapy (RT) to gross total resection (GTR) for patients
with newly diagnosed World Health Organization (WHO) grade II meningioma.
SECONDARY OBJECTIVES:
I. Overall survival (OS). II. Disease-specific survival (DSS). III. Toxicity (grade 3+,
exclusive of expected alopecia). IV. Neurocognitive function (NCF). V. Outcomes and patient
reported outcomes (PRO) measurements. VI. Adherence to protocol-specific target and normal
tissue parameters. VII. Concordance measurements of central versus parent-institution
pathology. VIII. Tissue microarray construction, and assessment of pHH3 mitotic index and
molecular correlates to OS.
OUTLINE: Patients are randomized to 1 of 2 arms after undergoing gross total resection.
ARM I: Patients undergo observation.
ARM II: Patients undergo radiation therapy 5 days a week over 6.5-7 weeks for a total of 33
fractions (59.4 Gy in 33 daily fractions of 1.8 Gy each).
After completion of study treatment, patients are followed up at 3, 6, and 12 months, every 6
months for year 2 and 3, then yearly for 10 years.
I. To determine, in terms of progression-free survival (PFS), the extent of clinical benefit
of the addition of adjuvant radiotherapy (RT) to gross total resection (GTR) for patients
with newly diagnosed World Health Organization (WHO) grade II meningioma.
SECONDARY OBJECTIVES:
I. Overall survival (OS). II. Disease-specific survival (DSS). III. Toxicity (grade 3+,
exclusive of expected alopecia). IV. Neurocognitive function (NCF). V. Outcomes and patient
reported outcomes (PRO) measurements. VI. Adherence to protocol-specific target and normal
tissue parameters. VII. Concordance measurements of central versus parent-institution
pathology. VIII. Tissue microarray construction, and assessment of pHH3 mitotic index and
molecular correlates to OS.
OUTLINE: Patients are randomized to 1 of 2 arms after undergoing gross total resection.
ARM I: Patients undergo observation.
ARM II: Patients undergo radiation therapy 5 days a week over 6.5-7 weeks for a total of 33
fractions (59.4 Gy in 33 daily fractions of 1.8 Gy each).
After completion of study treatment, patients are followed up at 3, 6, and 12 months, every 6
months for year 2 and 3, then yearly for 10 years.
Inclusion Criteria:
- PRIOR TO STEP 1 REGISTRATION:
- The patient must have a newly diagnosed unifocal intracranial meningioma, gross
totally resected, and histologically confirmed as WHO grade II based upon pathology
findings at the enrolling institution; WHO grade will be assigned according to WHO
2016 criteria
- Gross total resection (GTR) will be interpreted as modified Simpson grade 1-3 without
gross residual dural-based or extradural tumor; GTR must be confirmed both by modified
Simpson grade and by post-operative magnetic resonance imaging (MRI) findings
- Step 1 registration must occur within 180 days of the initial surgery; within this 180
day interval, a second surgery is permitted in order to achieve GTR, but even with a
second surgery, step 1 registration must occur within 180 days of the initial
resection
- For step 1 registration the operating neurosurgeon must provide the modified Simpson
grade
- GTR must be confirmed on post-operative imaging following the most recent surgery;
submission of both pre-operative and post-operative MRIs is required for patients; if
a second surgery is performed, submission of post-operative MRI is required and
pre-operative MRI is required only if obtained; all sequences obtained in the pre- and
post-operative MR imaging are to be submitted to National Radiology Group (NRG)
Oncology for study registration; imaging subsequent to enrollment must include pre and
post gadolinium contrast-enhanced three-dimensional spoiled gradient (SPGR),
magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI
scan and an axial T2 fluid attenuated inversion recovery (FLAIR) sequence; to yield
acceptable image quality, the gadolinium contrast-enhanced three-dimensional SPGR,
MP-RAGE, or TFE axial MRI scan should use the smallest possible axial slice thickness
not exceeding 1.5 mm; the post-operative MRI must be completed within sufficient time
to permit step 1 registration within 180 days of the initial resection; these same
conditions apply in the setting of a second surgical procedure, although if a second
surgery is completed, step 1 registration must still occur with 180 days of initial
surgery; computed tomography (CT) imaging is not required, but may be obtained if
desired clinically, for instance to assess calcifications or hyperostosis
- The patient or a legally authorized representative must provide study-specific
informed consent prior to study entry
- If the patient is a primary English speaker, the patient must participate in the NCF
and patient reported outcomes part of the study; if the patient is a primary French or
Spanish speaker, the patient must participate in the patient reported outcomes part of
the study
- NOTE: Central pathology review must occur between steps 1 and 2 of registration; once
appropriate pathology specimens are received, central pathology review will occur
within 15 days, and must confirm WHO grade II meningioma before the patient can
proceed to step 2 registration and randomization
- PRIOR TO STEP 2 REGISTRATION:
- Histologically confirmed diagnosis of WHO grade II meningioma confirmed by central
pathology review prior to step 2 registration
- History/physical examination, including neurologic examination within 60 days prior to
step 2 registration
- Post-operative Zubrod performance status 0-1 within 60 days prior to step 2
registration
- If the patient is a woman is of childbearing potential, a serum pregnancy test,
obtained within 14 days prior to step 2 registration, must be negative, and, if
randomized to receive radiation therapy, the woman must agree to use contraception
Exclusion Criteria:
- Optic nerve sheath meningioma, spinal or other extracranial meningioma, multiple
meningiomas, hemangiopericytoma
- Definitive evidence of metastatic meningioma
- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free
for a minimum of 3 years (carcinoma in situ of the breast, oral cavity, cervix,
melanoma in situ, or other non-invasive malignancies are permissible)
- Previous radiotherapy to the scalp, cranium, brain, or skull base and
radiation-induced meningiomas
- Major medical illnesses or psychiatric impairments, which in the investigators
opinion, will prevent administration or completion of the protocol therapy and/or
preclude informed consent; these include, but are not restricted to:
- Unstable angina and/or congestive heart failure requiring hospitalization at the
time of step 2 registration
- Transmural myocardial infarction within the last 6 months prior to step 2
registration
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of step 2 registration
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy at the time of step 2
registration
- Type II neurofibromatosis (NF2)
- Ailments entailing substantial increases in sensitivity and side effect risk from
radiation therapy (ataxia telangiectasia, Nijmegen breakage syndrome, and human
immunodeficiency virus (HIV) with CD4 count < 200 cells/microliter); HIV testing
is not required for eligibility for this protocol, and known HIV positive
patients are eligible, provided they are under treatment with highly active
antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter
within 30 days prior to step 2 registration
- Inability to undergo MRI with and without contrast (e.g. claustrophobia, non-MRI
compatible implant or foreign body, etc) or receive gadolinium; note that
patients with severe claustrophobia are permitted on this study if they are
willing and able to undergo MRI with adequate sedation or anesthesia
- Pregnancy and/or nursing females
We found this trial at
110
sites
2300 N Edward St
Decatur, Illinois 62526
Decatur, Illinois 62526
(217) 876-8121
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
Click here to add this to my saved trials
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Benny J. Liem
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Timothy J. Harris
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Richard L. Crownover
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
Click here to add this to my saved trials
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Michelle M. Kim
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
Click here to add this to my saved trials
Atlanta, Georgia 30322
Principal Investigator: Bree R. Eaton
Phone: 404-778-1868
Click here to add this to my saved trials
Atlanta, Georgia 30342
Principal Investigator: Bree R. Eaton
Phone: 412-339-5294
Click here to add this to my saved trials
Atlanta, Georgia 30303
Principal Investigator: Bree R. Eaton
Phone: 404-489-9164
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
Atlanta, Georgia 30309
(404) 605-5000
Principal Investigator: Adam W. Nowlan
Phone: 404-425-7943
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
Click here to add this to my saved trials
Auburn, California 95603
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
Click here to add this to my saved trials
Basking Ridge, New Jersey 07920
Principal Investigator: T. Jonathan Yang
Phone: 212-639-5007
Click here to add this to my saved trials
Bethlehem, Pennsylvania 18015
Principal Investigator: Nimisha Deb
Phone: 412-339-5294
Click here to add this to my saved trials
Birmingham, Alabama 35233
Principal Investigator: John B. Fiveash
Phone: 205-934-0220
Click here to add this to my saved trials
Boca Raton, Florida 33486
Principal Investigator: Gregg H. Goldin
Phone: 561-955-4800
Click here to add this to my saved trials
Click here to add this to my saved trials
Chadds Ford, Pennsylvania 19317
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
Principal Investigator: Colette Shen
Phone: 877-668-0683
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Scott M. Lindhorst
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
Click here to add this to my saved trials
303 East Superior Street
Chicago, Illinois 60611
Chicago, Illinois 60611
Principal Investigator: Sean Sachdev
Phone: 312-695-1301
Click here to add this to my saved trials
2049 E 100th St
Cleveland, Ohio 44106
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: John H. Suh
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
Click here to add this to my saved trials
1 Hospital Dr
Columbia, Missouri 65212
Columbia, Missouri 65212
(573) 882-2100
Principal Investigator: Tolga Tuncer
Phone: 573-882-7440
University of Missouri-Ellis Fischel Ellis Fischel Cancer Center's team of physician specialists and other trained...
Click here to add this to my saved trials
Columbus, Ohio 43210
Principal Investigator: Joshua D. Palmer
Phone: 800-293-5066
Click here to add this to my saved trials
Commack, New York 11725
Principal Investigator: T. Jonathan Yang
Phone: 631-623-4000
Click here to add this to my saved trials
10 Barnes West Drive
Creve Coeur, Missouri 63141
Creve Coeur, Missouri 63141
Principal Investigator: Christina I. Tsien
Phone: 800-600-3606
Click here to add this to my saved trials
Dallas, Texas 75390
Principal Investigator: Zabi Wardak
Phone: 214-648-7097
Click here to add this to my saved trials
100 North Academy Avenue
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Na Tosha N. Gatson
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
Click here to add this to my saved trials
Deerfield Beach, Florida 33442
Principal Investigator: Eric A. Mellon
Phone: 305-243-2647
Click here to add this to my saved trials
2200 Craig Road
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Principal Investigator: Benjamin E. Lawler
Phone: 800-782-8581
Click here to add this to my saved trials
Elyria, Ohio 44035
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
Click here to add this to my saved trials
Geneva, Illinois 60134
Principal Investigator: Vinai Gondi
Phone: 630-315-1918
Click here to add this to my saved trials
1117 29th St S
Great Falls, Montana 59405
Great Falls, Montana 59405
(406) 771-7300
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Benefis Healthcare- Sletten Cancer Institute Benefis Hospitals has 516 beds at its two campuses (that...
Click here to add this to my saved trials
Greenville, South Carolina 29605
Principal Investigator: Michael D. Zurenko
Phone: 864-241-6251
Click here to add this to my saved trials
Greenville, South Carolina 29615
Principal Investigator: Michael D. Zurenko
Phone: 864-241-6251
Click here to add this to my saved trials
Greer, South Carolina 29650
Principal Investigator: Michael D. Zurenko
Phone: 864-241-6251
Click here to add this to my saved trials
500 Westchester Avenue
Harrison, New York 10604
Harrison, New York 10604
Principal Investigator: T. Jonathan Yang
Phone: 212-639-7592
Click here to add this to my saved trials
80 Seymour St
Hartford, Connecticut 6102
Hartford, Connecticut 6102
(860) 545-5000
Principal Investigator: Ahmad Daher
Phone: 860-545-5363
The Hartford Hospital Hartford Hospital is the major teaching hospital affiliated with the University of...
Click here to add this to my saved trials
1301 Punchbowl St
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
(808) 538-9011
Principal Investigator: Richard Y. Lee
Phone: 412-339-5294
Queen's Medical Center The Queen's Medical Center, located in downtown Honolulu, Hawaii, is a private,...
Click here to add this to my saved trials
Honolulu, Hawaii 96817
Principal Investigator: Richard Y. Lee
Phone: 808-547-6881
Click here to add this to my saved trials
Houston, Texas 77030
Principal Investigator: Debra N. Yeboa
Phone: 877-312-3961
Click here to add this to my saved trials
Indianapolis, Indiana 46202
Principal Investigator: Gordon A. Watson
Phone: 317-278-5632
Click here to add this to my saved trials
535 Barnhill Dr
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
(888) 600-4822
Principal Investigator: Gordon A. Watson
Phone: 317-278-5632
Indiana University Melvin and Bren Simon Cancer Center At the IU Simon Cancer Center, more...
Click here to add this to my saved trials
Iowa City, Iowa 52242
Principal Investigator: Mark C. Smith
Phone: 800-237-1225
Click here to add this to my saved trials
310 Sunnyview Ln
Kalispell, Montana 59901
Kalispell, Montana 59901
(406) 752-5111
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
Click here to add this to my saved trials
1 Medical Center Dr
Lebanon, New Hampshire 03756
Lebanon, New Hampshire 03756
(603) 650-5000
Principal Investigator: Alan C. Hartford
Phone: 800-639-6918
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
Click here to add this to my saved trials
Lewisburg, Pennsylvania 17837
Principal Investigator: Na Tosha N. Gatson
Phone: 570-374-8555
Click here to add this to my saved trials
4733 Sunset Blvd
Los Angeles, California 90027
Los Angeles, California 90027
(800) 954-8000
Principal Investigator: Michael R. Girvigian
Phone: 800-398-3996
Kaiser Permanente Los Angeles Medical Center We've been there for you in the past, providing...
Click here to add this to my saved trials
1983 Marengo St
Los Angeles, California 90033
Los Angeles, California 90033
(323) 226-2622
Principal Investigator: Eric L. Chang
Phone: 323-865-0451
Los Angeles County-USC Medical Center The origins of LAC+USC Medical Center date back to 1878,...
Click here to add this to my saved trials
1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
Principal Investigator: Eric L. Chang
Phone: 323-865-0451
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
Click here to add this to my saved trials
600 Highland Ave
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: Steven P. Howard
Phone: 800-622-8922
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
Click here to add this to my saved trials
2160 South 1st Avenue
Maywood, Illinois 60153
Maywood, Illinois 60153
(888) 584-7888
Principal Investigator: Edward Melian
Phone: 708-226-4357
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
Click here to add this to my saved trials
Menomonee Falls, Wisconsin 53051
Principal Investigator: Joseph A. Bovi
Phone: 262-257-5100
Click here to add this to my saved trials
9485 Mentor Ave
Mentor, Ohio 44060
Mentor, Ohio 44060
(440) 205-5755
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
Lake University Ireland Cancer Center Lake Health is a private, not-for-profit leader in community health...
Click here to add this to my saved trials
Miami, Florida 33136
Principal Investigator: Eric A. Mellon
Phone: 305-243-2647
Click here to add this to my saved trials
Miami, Florida 33176
Principal Investigator: Minesh P. Mehta
Phone: 786-596-2000
Click here to add this to my saved trials
Middletown, New Jersey 07748
Principal Investigator: T. Jonathan Yang
Phone: 212-639-7592
Click here to add this to my saved trials
9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 805-3666
Principal Investigator: Joseph A. Bovi
Phone: 414-805-4380
Froedtert and the Medical College of Wisconsin Froedtert Health combines with the Medical College of...
Click here to add this to my saved trials
1700 Coffee Rd
Modesto, California 95355
Modesto, California 95355
(209) 526-4500
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
Memorial Medical Center Memorial is affiliated with Sutter Health, a family of not-for-profit hospitals, physician...
Click here to add this to my saved trials
225 Summit Avenue
Montvale, New Jersey 07645
Montvale, New Jersey 07645
Principal Investigator: T. Jonathan Yang
Phone: 212-639-7592
Click here to add this to my saved trials
Nashville, Tennessee 37232
Principal Investigator: Lola Chambless
Phone: 800-811-8480
Click here to add this to my saved trials
New Brunswick, New Jersey 08903
Principal Investigator: Joseph P. Weiner
Phone: 732-235-8675
Click here to add this to my saved trials
New York, New York 10032
Principal Investigator: Tony J. Wang
Phone: 212-305-6361
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: T. Jonathan Yang
Phone: 212-639-7592
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials
Newark, Delaware 19713
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
Click here to add this to my saved trials
4755 Ogletown-Stanton Road
Newark, Delaware 19718
Newark, Delaware 19718
302-733-1000
Principal Investigator: Gregory A. Masters
Phone: 302-623-4450
Christiana Care Health System - Christiana Hospital A 913-bed, 1.3-million-square-foot, modern facility in Newark, Delaware,...
Click here to add this to my saved trials
Oakland, California 94611
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
940 NE 13th St
Oklahoma City, Oklahoma 73190
Oklahoma City, Oklahoma 73190
(405) 271-6458
Principal Investigator: J. S. Thompson
Phone: 405-271-8777
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
Click here to add this to my saved trials
Emile St
Omaha, Nebraska 68198
Omaha, Nebraska 68198
(402) 559-4000
Principal Investigator: Chi Zhang
Phone: 402-559-6941
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
Click here to add this to my saved trials
Orange, California 92868
Principal Investigator: Xiao-Tang Kong
Phone: 877-827-8839
Click here to add this to my saved trials
Orlando, Florida 32803
Principal Investigator: Carlos A. Alemany
Phone: 407-303-2090
Click here to add this to my saved trials
875 Blake Wilbur Drive
Palo Alto, California 94304
Palo Alto, California 94304
Principal Investigator: Scott G. Soltys
Phone: 650-498-7061
Click here to add this to my saved trials
Pennington, New Jersey 08534
Principal Investigator: Navid Redjal
Phone: 800-255-3440
Click here to add this to my saved trials
111 S 11th St
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Wenyin Shi
Phone: 215-955-6084
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
Click here to add this to my saved trials
Phoenix, Arizona 85013
Principal Investigator: C. L. Rogers
Phone: 412-339-5294
Click here to add this to my saved trials
Phoenix, Arizona
Principal Investigator: Kenneth W. Merrell
Phone: 855-776-0015
Click here to add this to my saved trials
Portland, Maine 04102
Principal Investigator: Matthew D. Cheney
Phone: 207-885-7565
Click here to add this to my saved trials
1015 NW 22nd Ave
Portland, Oregon 97210
Portland, Oregon 97210
(503) 413-7711
Principal Investigator: Andrew Y. Kee
Phone: 800-220-4937
Legacy Good Samaritan Hospital and Medical Center Located in the heart of Northwest Portland, Legacy...
Click here to add this to my saved trials
Rancho Cordova, California 95670
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
Rehoboth Beach, Delaware 19971
Principal Investigator: Gregory A. Masters
Phone: 302-645-3100
Click here to add this to my saved trials
Rochester, Minnesota 55905
Principal Investigator: Kenneth W. Merrell
Phone: 855-776-0015
Click here to add this to my saved trials
Rockville Centre, New York 11570
Principal Investigator: T. Jonathan Yang
Phone: 516-256-3651
Click here to add this to my saved trials
Rohnert Park, California 94928
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
Roseville, California 95678
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
Roseville, California 95661
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
Click here to add this to my saved trials
Sacramento, California 95823
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
Sacramento, California 95819
Principal Investigator: Christopher U. Jones
Phone: 916-454-6500
Click here to add this to my saved trials
Saint Johnsbury, Vermont 05819
Principal Investigator: Alan C. Hartford
Phone: 802-473-4100
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Christina I. Tsien
Phone: 800-600-3606
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
Click here to add this to my saved trials
Saint Louis, Missouri 63129
Principal Investigator: Christina I. Tsien
Phone: 800-600-3606
Click here to add this to my saved trials
150 Entranceway Drive
Saint Peters, Missouri 63376
Saint Peters, Missouri 63376
Principal Investigator: Christina I. Tsien
Phone: 800-600-3606
Click here to add this to my saved trials
700 Lawrence Expy
Santa Clara, California 95051
Santa Clara, California 95051
(408) 851-1000
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Kaiser Permanente Medical Center - Santa Clara At Kaiser Permanente Santa Clara, members and patients...
Click here to add this to my saved trials
Scarborough, Maine 04074
Principal Investigator: Matthew D. Cheney
Phone: 207-396-8090
Click here to add this to my saved trials
13400 E. Shea Blvd.
Scottsdale, Arizona 85259
Scottsdale, Arizona 85259
480-301-8000
Principal Investigator: Kenneth W. Merrell
Phone: 855-776-0015
Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
Click here to add this to my saved trials
Seaford, Delaware 19973
Principal Investigator: Gregory A. Masters
Phone: 302-645-3100
Click here to add this to my saved trials
1959 NE Pacific St
Seattle, Washington 98195
Seattle, Washington 98195
(206) 598-3300
Principal Investigator: Lia M. Halasz
Phone: 800-804-8824
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
Click here to add this to my saved trials
Seneca, South Carolina 29672
Principal Investigator: Michael D. Zurenko
Phone: 864-241-6251
Click here to add this to my saved trials
Somerset, New Jersey 08873
Principal Investigator: T. Jonathan Yang
Phone: 877-967-7628
Click here to add this to my saved trials
Somerville, New Jersey 08876
Principal Investigator: Kathleen C. Toomey
Phone: 908-685-2481
Click here to add this to my saved trials
South San Francisco, California 94080
Principal Investigator: Samantha A. Seaward
Phone: 877-642-4691
Click here to add this to my saved trials
Spartanburg, South Carolina 29307
Principal Investigator: Michael D. Zurenko
Phone: 864-241-6251
Click here to add this to my saved trials