Dual Time Point FDG PET-MR Imaging Optimization for the Evaluation of Glioblastoma

Imaging Procedures:

If you agree to take part in this study, you will come to the Diagnostic Imaging clinic for
your FDG PET/CT scans. If you have not had your standard of care MRI scan done already, it
will be done on the day of the FDG PET/CT scans.

The contrast drug will be injected into a vein in your arm through a standard IV over about a
minute.

One (1) hour after you receive the contrast drug, you will be moved to the FDG PET-CT scanner
where you will have a brain and whole body scan, which will take about 30 minutes. This is a
research scan.

If you have not had your standard-of-care MRI scan of your brain already, it will be done at
this time. This MRI will take about 45 minutes.

You will come back to the clinic for 2 more FDG PET-CT scans at 4 - 5 hours and at 7 - 8
hours after receiving the contrast drug. The scanning time will be about 20 - 30 minutes each
time. These are the research scans.

You must fast (have nothing to eat or drink except water) for at least 6 hours before each
scan. When you are allowed to eat, you should eat a low carbohydrate, high protein meal (for
example, baked chicken with a side of asparagus, broccoli, mushrooms, or any green
vegetable/salad). You should also drink about 6-8 glasses of water (each glass should be
about 8 ounces). The study staff will give you a handout with specific diet instructions you
must follow before the PET scan.

Information will also be collected from your medical record.

Length of Study Participation:

Your active participation in this study will be over after your last PET-CT scan is complete.

This is an investigational study. The FDG PET-CT and MRIs are delivered using FDA approved
and commercially available methods. Comparing the results from different imaging time points
after giving the contrast drug is investigational.

Up to 20 participants will be enrolled in this study. All will take part at MD Anderson.

Inclusion Criteria:

1. Pre-operative adult (>19 years of age) patients with biopsy proven (as opposed to
being status post definitive surgical therapy) or highly suspected glioblastoma of the
brain.

2. Cases without prior biopsy will be chosen based upon consensus of an MD Anderson
faculty neuroradiologist and neurosurgeon for high probability of representing a
glioblastoma

3. T1 post contrast lesion size greater than or equal to 10 mm

Exclusion Criteria:

1. Children

2. Definitive / gross total lesion resection

3. Prior brain cancer

4. Prior whole brain radiation

5. Known history of cerebrovascular disease, dementia or prior non-mild traumatic brain
injury

6. Known allergy to FDG or gadolinium based contrast agents

7. Blood glucose >200

8. Pregnant women are excluded

9. Patients less than 19 years of age will be excluded.