An Open-label Single Dose Randomized, Parallel Group Study Followed by Single-blind Repeat Dosing, to Compare the Relative Bioavailability of GSK2212836.

Inclusion Criteria:

- AST, ALT, alkaline phosphatase and bilirubin less than 1.5xULN (isolated bilirubin
>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including [medical history, physical examination, laboratory tests and
ECGs. A subject with a clinical abnormality or laboratory parameters outside the
reference range for the population being studied may be included only if the
Investigator and the GSK Medical Monitor agree that the finding is unlikely to
introduce additional risk factors and will not interfere with the study procedures.

- Male or female between 18 and 50 years of age inclusive, at the time of signing the
informed consent.

- A female subject is eligible to participate if she is of Child-bearing potential and
agrees to use one of the contraception methods listed in the protocol.

- Body weight greater than or equal to 50kg (110 lbs) for men and greater than or equal
to 45 kg for women and BMI within the range 24-34kg/m2 (inclusive).

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

- Average QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch
Block.

Exclusion Criteria:

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- A positive pre-study drug/alcohol screen.

- A positive test for HIV antibody.

- History of regular alcohol consumption within 6 months of the study defined as:

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
supplements (including St John's Wort) within 7 days (or 14 days if the drug is a
potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first
dose of study medication, unless in the opinion of the Investigator and GSK Medical
Monitor the medication will not interfere with the study procedures or compromise
subject safety.

- Use of omega-3 fatty acid supplements and/or fish or fish oil products from screening
until final assessment and unwilling to abstain from eating oily fish (salmon,
albacore tuna, mackerel, sardines, etc.) during the course of the study.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- History of sensitivity or known allergy to fish and /or shellfish.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Pregnant females as determined by positive hCG test at screening (serum) or prior to
dosing (urine).

- Lactating females.

- Unwillingness or inability to follow the procedures outlined in the protocol.

- Subject is mentally or legally incapacitated.

- History of sensitivity to heparin or heparin-induced thrombocytopenia.

- Unable to abstain from smoking tobacco- or use of nicotine-containing products while
in the clinic.