Physiologic Assessment of Coronary Stenosis Following PCI

Inclusion Criteria:

1. Subject must be > 18 years old

2. Subjects presenting with stable angina, silent ischemia or non-ST-elevation ACS
(unstable angina or biomarker positive)

3. Single vessel CAD with at least 2 separate lesions (≥10 mm apart) of ≥40% stenosis or
a single long lesion of ≥20mm OR multi-vessel CAD, defined as at least 2 vessels with
≥40% stenosis

4. Pre-PCI iFR performed in all vessels intended for PCI

5. Pre-PCI iFR of <0.90 of at least 1 stenosis

6. Subjects are able and willing to comply with scheduled visits and tests and to provide
informed consent.

Exclusion Criteria:

1. Pregnant or planning to become pregnant for the duration of the study

2. Acute STEMI within the past 7 days

3. Cardiogenic shock (sustained (>10 min) systolic blood pressure < 90 mmHg in absence of
inotropic support or the presence of an intra-aortic balloon pump).

4. Ionotropic or temporary pacing requirement

5. Sustained ventricular arrhythmias

6. Prior CABG

7. Known ejection fraction ≤30%

8. Chronic Total Occlusion (CTO)

9. Known severe mitral or aortic stenosis.

10. Any known medical comorbidity resulting in life expectancy < 12 months.

11. Participation in any investigational study that has not yet reached its primary
endpoint.

12. Known severe renal insufficiency (eGFR <30 ml/min/1.72 m2).

13. TIMI flow <3 at baseline

14. Intra-coronary thrombus on baseline angiography