Alkaline Phosphatase Level in Pregnancy and Its Association With Birth Weight



Status:Recruiting
Conditions:Obesity Weight Loss, Women's Studies
Therapuetic Areas:Endocrinology, Reproductive
Healthy:No
Age Range:18 - Any
Updated:12/30/2018
Start Date:June 14, 2017
End Date:May 2019
Contact:Ganga Devaiah, MS
Email:ganga_devaiah@trihealth.com
Phone:513-862-2341

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Trial Summary
Trial Overview
Inclusion Criteria
Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its
levels are normally increased in pregnancy. Therefore, it would be reasonable to hypothesize
that alkaline phosphatase would be low to low normal in cases of low birth weight /
intrauterine growth restriction (IUGR)/ placental insufficiency.

The purpose of this study will be to determine if alkaline phosphatase can be used as a
predictor for suboptimal fetal growth, placental insufficiency and low birth weight (birth
weight less than 2500 grams). It will also help determine if alkaline phosphatase can be used
as a screening tool for low birth weight/IUGR at the time of the 24 to 28 week labs.

Inclusion Criteria:

• Patients enrolled between 24w0d and 28w6d weeks gestational age will be included. The
blood specimen of the patients enrolled will be held until delivery.

Exclusion Criteria:

- Multiple gestations

- Known congenital malformations (any, except Pyelectasis)

- Chronic hypertension

- Inflammatory bowel disease (IBD)

- Gall bladder disease

- Active bone disease (ie, skeletal dysplasia, healing fracture)

- Active liver disease (ie, hepatitis, cholestasis, cholelithiasis (gallstones))

- Pre-existing type 1 and 2 Diabetes

- Early-onset IUGR
We found this trial at
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Good Samaritan TriHealth Hospital
Cincinnati, Ohio 45220
Phone: 513-862-2341
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Cincinnati, OH
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