Study of PET Imaging With 18F-TFB in Patients With Thyroid Cancer

Inclusion Criteria:

- Patients must have histologically or cytologically confirmed thyroid carcinoma of
follicular origin (including papillary and its respective variants).

- Patients should have tumors that are radiographically evident on CT or MRI

- Age ≥ 18 years.

- ECOG performance status ≤ 2 (or Karnofsky ≥60%).

- Patients must have normal organ and bone marrow function as defined below:

- Absolute neutrophil count (ANC) > 1.5x10^9/L

- Hemoglobin ≥ 9 g/dL

- Platelets ≥ 100 x 10^9/L

- Albumin ≥ 2.5 g/dL

- Total bilirubin ≤ 1.5x institutional ULN

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2x
institutional ULN unless it is related to the primary disease

- Creatinine ≤ 1.5 mg/dL OR calculated creatinine clearance (Cockcroft-Gault
formula) ≥ 50 mL/min OR 24-hour urine creatinine clearance ≥ 50 mL/min

- Negative pregnancy test within 7 days prior to starting the study in premenopausal
women. Women of non-childbearing potential may be included without pregnancy test if
they are either surgically sterile or have been postmenopausal for ≥ 1 year.

- Fertile men and women must use an effective method of contraception during treatment
and for at least 6 months after completion of treatment as directed by their
physician. Effective methods of contraception are defined as those, which result in a
low failure rate (i.e., less than 1% per year) when used consistently and correctly
(for example implants, injectables, combined oral contraception or intra-uterine
devices). At the discretion of the Investigator, acceptable methods of contraception
may include total abstinence in cases where the lifestyle of the patient ensures
compliance. (Periodic abstinence [e.g., calendar, ovulation, symptothermal,
postovulation methods] and withdrawal are not acceptable methods of contraception.)

- Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection or psychiatric illness/social situations that would limit compliance with
study requirements.

- Pregnant, lactating, or breast feeding women.

- Patients unable to follow a low iodine diet or requiring medication with high content
in iodide (amiodarone).

- Patients who received iodinated intravenous contrast as part of a radiographic
procedure within 3 months of study registration. Those that have had iodinated
intravenous contrast for CT imaging within this time frame may still be eligible if a
urinary iodine analysis reveals that the excess iodine has been adequately cleared
after the last intravenous contrast administration.

- Unwillingness or inability to comply with study procedures.