Evaluation of Changes in Skin Carotenoid Scores in Medical Students Following a Dietary Supplement-based Intervention
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 89 |
| Updated: | 1/10/2019 |
| Start Date: | May 2015 |
| End Date: | August 2019 |
Evaluation of Changes in Skin Carotenoid Score in Medical Students Following a Dietary Supplement-based Intervention
Skin Carotenoid Scores (SCS) are a biomarker of overall antioxidant status. This study
extends an earlier study in which an increase in skin carotenoid scores (SCS) was observed in
subjects who increased their intake of fruits and vegetables. The scores were determined
using the Raman Spectroscopy. In that study subjects were assigned to one of four groups
based on their baseline SCS. For unknown reasons, the groups with the highest and lowest
baseline SCS failed to show an increase whereas the two intermediate groups did. One possible
explanation might be that intakes varied more than expected and was not obvious due to
self-reporting of intake of fruits and vegetables with different contents.
extends an earlier study in which an increase in skin carotenoid scores (SCS) was observed in
subjects who increased their intake of fruits and vegetables. The scores were determined
using the Raman Spectroscopy. In that study subjects were assigned to one of four groups
based on their baseline SCS. For unknown reasons, the groups with the highest and lowest
baseline SCS failed to show an increase whereas the two intermediate groups did. One possible
explanation might be that intakes varied more than expected and was not obvious due to
self-reporting of intake of fruits and vegetables with different contents.
This current project will be an interventional, non-invasive study examining changes in skin
carotenoid levels over time in individuals who increase their carotenoid intake by taking a
dietary supplement containing a known amount of carotenoids. After a two-week control period
eating their normal diet, forty medical students meeting study inclusion criteria will be
asked to take a dietary supplement over an eight week period of time. Students will be given
twin-sachet packets of LifePak Nano supplements containing five capsules (dry ingredients)
and two CR-6 Liponutrient softgel capsules (liquid ingredients, including omega-3 fatty acids
and nanosized carotenoids). These will be taken twice a day with eight ounces of liquid at
the morning and evening meal. SCS will be measured every 2 weeks. At the end of this period,
the students will be asked to discontinue dietary supplement intake and follow their usual
diet for 2 weeks then their SCS measured again.
carotenoid levels over time in individuals who increase their carotenoid intake by taking a
dietary supplement containing a known amount of carotenoids. After a two-week control period
eating their normal diet, forty medical students meeting study inclusion criteria will be
asked to take a dietary supplement over an eight week period of time. Students will be given
twin-sachet packets of LifePak Nano supplements containing five capsules (dry ingredients)
and two CR-6 Liponutrient softgel capsules (liquid ingredients, including omega-3 fatty acids
and nanosized carotenoids). These will be taken twice a day with eight ounces of liquid at
the morning and evening meal. SCS will be measured every 2 weeks. At the end of this period,
the students will be asked to discontinue dietary supplement intake and follow their usual
diet for 2 weeks then their SCS measured again.
Inclusion Criteria:
1. Medical students must be willing to maintain the increased consumption of dietary
supplements, two twin-sachet packets of seven (7) supplements twice per day, for the
entire eight-week experimental period, to maintain the logs and to report at each of
the times that measurements will be made. Individuals taking non-Pharmanex dietary
supplements e.g. vitamins, minerals, herbals, and/or antioxidants will be asked to
discontinue use at the time of the consenting to the study. Study supplements will
replace all previous dietary supplements.
2. BMI between 20 and 29.9
3. Non-smoker, non-pregnant, non-lactating
4. No use of tanning beds or sunless tanning products during the study
Exclusion Criteria:
1. Prior participation in the previous study (L14 -128)
2. Individuals suffering from any chronic illness requiring ongoing medication, such as
diabetes, hypertension, heart disease, GI disorders or other metabolic disorders
3. Individuals allergic or intolerant to shellfish,
4. pregnant or lactating women,
5. smokers
6. individuals with BMI > 30
7. Prior ingestion of LifePak Nano or other Pharmanex dietary supplements within the past
3 months.
8. SCS score less than 10,000 (< 10,000)
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