A Study of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Patients With Advanced Stage Classical Hodgkin Lymphoma, Who Are Relapsed/ Refractory or Who Are Not Eligible for Autologous Stem Cell Transplant,



Status:Recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:May 16, 2017
End Date:July 27, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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Trial Summary
Trial Overview
Inclusion Criteria

Randomized, Open-label, Phase 3 Trial of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Participants With Relapsed Refractory or Ineligible for Autologous Stem Cell Transplant (ASCT) Advanced Stage Classical Hodgkin Lymphoma (CheckMate 812: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 812)

The purpose of this study is to determine whether an investigational immuno-therapy
combination, nivolumab with Brentuximab vedotin compared to Brentuximab vedotin alone is safe
and effective in the treatment of relapsed and refractory Classical Hodgkin Lymphoma. The
participants of this trial will comprise of patients who have relapsed or did not respond to
treatment and are not eligible for stem cell transplant


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1

- Participants must have a pathologic diagnosis of classical Hodgkin lymphoma (cHL) who
are relapsed or refractory with one of the following:

I. Autologous stem cell transplant (ASCT) ineligible patients

ii. Patients after failure of ASCT

- Must have at least one lesion that is > 15 mm (1.5 cm) in the longest diameter and
avid by Fluoro Deoxy Glucose (FDG) Positron Emission Tomography (PET) scan

Exclusion Criteria:

- Known central nervous system lymphoma

- Participants with nodular lymphocyte-predominant Hodgkin lymphoma (HL)

- Participants with known history of pancreatitis or progressive multifocal
leukoencephalopathy (PML)

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
52
sites
Tulane University Health Sciences Center
1430 Tulane Ave Suite SL32
New Orleans, Louisiana 70112
(504) 588-5912
Tulane University Health Sciences Center One of the nation's most recognized centers for medical education,...
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Roswell Park Cancer Institute
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Phone: 716-845-4359
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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University of Arkansas for Medical Sciences
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Phone: 615-936-3236
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Orlando Health
24 Sturtevant St
Orlando, Florida 32806
Phone: 321-841-1907
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Local Institution
520 Smollett Street
Albury, New South Wales 2640
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Memorial Sloan-Kettering Cancer Center (MSKCC) - Basking Ridge
Basking Ridge, New Jersey 07920
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Dana Farber Cancer Institute (DFCI)
Boston, Massachusetts 02115
Phone: 617-582-7292
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Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-8856
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Local Institution
Charlottesville, Virginia 22908
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University of Texas Southwestern Medical Center
1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
Phone: 214-648-7030
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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Karmanos Cancer Institute
Detroit, Michigan 48201
Phone: 313-576-9689
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Detroit, MI
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City of Hope National Medical Center
1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Phone: 626-218-9108
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Phone: 919-681-4769
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Parkview Cancer Center
Fort Wayne, Indiana 46845
Phone: 574-364-2974
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East Carolina University Brody School of Medicine(ECU)
Greenville, North Carolina 27834
Phone: 252-744-4924
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Bon Secours Saint Francis Cancer Center
Greenville, South Carolina 29607
Phone: 864-603-6222
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John Theurer Cancer Center at the Hackensack University Medical Center
92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-5168
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Memorial Sloan Kettering Cancer Center ( Site 1229)
500 Westchester Avenue
Harrison, New York 10604
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
Phone: 713-792-1871
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Baptist Cancer Institute
Jacksonville, Florida
Phone: 904-202-7332
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Mercy Clinic Oncology and Hematology - Joplin
3001 McClelland Blvd
Joplin, Missouri 64804
Phone: 417-556-3074
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U.T. Medical Center Cancer Institute
Knoxville, Tennessee 37920
Phone: 865-541-1812
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Center for Biomedical Research
Knoxville, Tennessee 37909
Phone: 865-934-2670
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University of California, San Diego (UCSD)
La Jolla, California 92093
Phone: 858-822-1921
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Pacific Shores Medical Group
Long Beach, California 90813
Phone: 562-590-0345
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University of Califomia, Los Angeles
Los Angeles, California 90095
Phone: 949653295920829
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Louisville Oncology
Louisville, Kentucky 40202
Phone: 502-899-6147
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Miami Cancer Institute Baptist Health South Florida
Miami, Florida 33143
Phone: 786-527-8866
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Memorial Sloan Kettering Cancer Center-Monmouth
480 Red Hill Road
Middletown, New Jersey 07748
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Dr. Moh'd Khushman MD, Office of
1660 Spring Hill Avenue
Mobile, Alabama 36604
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Ochsner Clinic Foundation
New Orleans, Louisiana 70121
Phone: 504-842-8084
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Local Institution
New York, New York 10016
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Vista Oncology - East Olympia
420 McPhee Road Southwest
Olympia, Washington 98502
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Local Institution
Palo Alto, California 94304
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Local Institution
Philadelphia, Pennsylvania 19102
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Univ of Pennsylvania
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-662-2062
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Hartford Healthcare Cancer Institute at The Hospital of Central Connecticut
Plainville, Connecticut 06062
Phone: 860-696-4958
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Local Institution
4050 Wake Forest Road
Raleigh, North Carolina 27609
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Local Institution
Rochester, Minnesota 55905
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Local Institution
Rochester, New York 14642
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Memorial Sloan-Kettering Cancer Center - Rockville Centre
Rockville Centre, New York 11570
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UC Davis Comprehensive Cancer Center
4501 X St
Sacramento, California 95817
(916) 734-5800
Phone: 916-734-1455
UC Davis Comprehensive Cancer Center When faced with cancer, you want the best hope for...
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Local Institution
San Antonio, Texas 78229
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Swedish Cancer Institute
Seattle, Washington 98104
Phone: 206-215-3350
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Greenville Health System Cancer Institute
Spartanburg, South Carolina 29307
Phone: 864-987-1258
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Mercy Medical Research Institute
Springfield, Missouri 65807
Phone: 417-820-9742
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H. Lee Moffit Cancer Center & Research Institute
Tampa, Florida
Phone: 813-745-2591
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Georgetown University Hospital
3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 444-2000
Phone: 202-687-7354
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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University of Kansas Hospital
Westwood, Kansas 66205
Phone: 913-588-8694
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Wake Forest University Health Sciences
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
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