The Use of Low Molecular Weight Heparin in Traumatic Brain Injury
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Cardiology, Hospital, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/28/2017 |
| Start Date: | December 2002 |
| End Date: | August 2005 |
To study the safety and efficacy of early administration of Low Molecular Weight Heparin to
patients with traumatic brain injury.
patients with traumatic brain injury.
Venous thromboembolic (VTE) prophylaxis in trauma patients is a critical clinical problem.
Patients with traumatic brain injury usually have effective VTE prophylaxis withheld
secondary to concerns of exacerbating intracranial hemorrhage. This study examines the
safety and efficacy of early administration (within 24 hrs of admission) of low molecular
weight heparin to this patient population with very high VTE risk.
Patients with traumatic brain injury usually have effective VTE prophylaxis withheld
secondary to concerns of exacerbating intracranial hemorrhage. This study examines the
safety and efficacy of early administration (within 24 hrs of admission) of low molecular
weight heparin to this patient population with very high VTE risk.
Inclusion Criteria:
- Blunt traumatic brain injury (Marshall II-V)
- Stable 6 hr. head CT
- Stable hemoglobin
Exclusion Criteria:
- Premorbid coagulopathy
- Pregnancy
- < 18 y.o.
- Need for therapeutic anticoagulation
- Heparin allergy
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