HELP Prevent Cancer Pilot Study

The Healthy Living Partnerships to Prevent Diabetes (HELP PD) study successfully translated
the Diabetes Prevention Program (DPP) weight-loss lifestyle intervention in Winston-Salem,
North Carolina by delivering the intervention via a partnership between a local diabetes
education program with lay community health workers. This study documented a 7% weight loss
and 4 mg/dl decrease in fasting blood glucose in patients with prediabetes in 1 year at
promote healthy weight loss (1-2 pounds per week). These lifestyle strategies significantly
lower costs than the DPP. The HELP PD lifestyle intervention focuses on restricting calories
(while improving dietary quality) and increasing physical activity to allow participants to
achieve an energy deficient state to are essential to reduce risk for type 2 diabetes but
also for a multitude of chronic diseases where excess body weight plays a critical role in
the development and exacerbation of the disease. In light of the community-based partnership
on which HELP PD was based and the relatively low costs of program administration, the HELP
PD model has the potential to be a highly effective and sustainable long-term approach to
cancer prevention as well. This pilot study will be the initial step to determine feasibility
of implementing the Healthy Living Partnerships to Prevent Cancer (HELP PC) in the Dan River
Region of Southern Virginia through a partnership between researchers and colleagues from
Wake Forest Comprehensive Cancer Center, Virginia Polytechnic Institute and State University,
Danville Hematology and Oncology at the Danville Regional Medical Center, Resource Center of
Southern Virginia in Danville, and Danville Regional Medical Center. Wake Forest will serve
as the lead site in this study.

Inclusion Criteria:

- English Proficiency: Able to read/understand English at or above a level sufficient to
comprehend recruitment and intervention materials.

- Body Mass Index: BMI > 25 kg/m2.

Exclusion Criteria:

- Weight Loss: Currently involved in a supervised program for weight loss.

- Medications: Use of insulin or other diabetes medications that would require
additional medical monitoring during weight-loss; use of medications for weight loss
or that may impact weight or glucometabolic function (e.g. corticosteroids).

- Recent History of Cardiovascular Disease: Clinical history of cardiovascular disease
(CVD) occurring within the past 6 months, including myocardial infarction, angina,
coronary revascularization, stroke, transient ischemic attack (TIA), carotid
revascularization, peripheral arterial disease, and congestive heart failure.

- Hypertension: Uncontrolled high blood pressure: BP > 160/100. Persons can be
re-screened after controlled.

- Pregnancy: Pregnancy, breast feeding, or planning pregnancy within 1 year.

- Other Chronic Conditions: Other chronic disease likely to limit lifespan to less than
2-3 years, including any cancer requiring treatment in past 5 years except
non-melanoma skin cancer.