Impact of CPAP Level on V/Q Mismatch in Premature Infants

Status:	Recruiting
Conditions:	Cardiology, Women's Studies, Pulmonary
Therapuetic Areas:	Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases, Reproductive
Healthy:	No
Age Range:	Any
Updated:	5/4/2018
Start Date:	February 1, 2017
End Date:	September 30, 2019
Contact:	Carolyn McAnlis
Email:	mcanlisc@email.chop.edu
Phone:	2674260268

Impact of Continuous Positive Airway Pressure Level on Ventilation/Perfusion Mismatch in Premature Infants: a Phase II Clinical Trial

Continuous positive airway pressure (CPAP) is used in premature infants to maintain lungs
open and facilitate gas exchange. When ventilation/perfusion (V/Q) mismatch is present, areas
of the lung that are open for gas exchange do not match up with the areas of the lung that
are receiving blood for gas exchange. This study measure the responsiveness of V/Q mismatch
to changes in the amount (or level) of CPAP.

Inclusion Criteria:

1. Born at 27-35 weeks gestational age (GA) by best obstetric estimate, determined by the
clinical obstetric team during antepartum admission.

2. Age limits: 24 hours of age - 35 weeks corrected gestational age.

3. On continuous CPAP support between 4-8 cm H2O for greater than 24 hours, as document
on the bedside infant flow sheet.

4. Supplemental oxygen requirement, with a fraction of inspired oxygen (FiO2) 0.25 for at
least 2 consecutive hours, as documented on the bedside infant flow sheet.

Exclusion Criteria:

1. Congenital anomalies, as determined by the clinical supervising physician.

2. Current or prior air leak syndrome, as determined by the clinical supervising
physician.

We found this trial at

sites

Hospital of the University of Pennsylvania

3400 Spruce St
Philadelphia, Pennsylvania 19104

(215) 662-4000