The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/14/2017 |
| Start Date: | February 16, 2017 |
| End Date: | March 2018 |
This is a prospective multicenter study. All patients presenting for revision hip or knee
arthroplasty for all indications under the respective surgeon's care may be eligible. Per
standard of care preoperatively, all patients must have blood drawn for erythrocyte
sedimentation rate(ESR), C-reactive protein(CRP) and D-dimer. Aspiration of the joint in
question may be performed at the discretion of the treating surgeon and results documented.
Intraoperative samples will also be collected and sent for NGS analysis
arthroplasty for all indications under the respective surgeon's care may be eligible. Per
standard of care preoperatively, all patients must have blood drawn for erythrocyte
sedimentation rate(ESR), C-reactive protein(CRP) and D-dimer. Aspiration of the joint in
question may be performed at the discretion of the treating surgeon and results documented.
Intraoperative samples will also be collected and sent for NGS analysis
Pre-operative D-dimer testing should be performed if this is in keeping with the local
institutional standard of care. Otherwise, D-dimer testing will be omitted from the
pre-operative panel of tests collected.
NGS results will be made available to the Investigator. Treatment will remain within keeping
with the Investigator's standard of care. NGS results may be used at the discretion of the
treating surgeon in guiding patient treatment.
institutional standard of care. Otherwise, D-dimer testing will be omitted from the
pre-operative panel of tests collected.
NGS results will be made available to the Investigator. Treatment will remain within keeping
with the Investigator's standard of care. NGS results may be used at the discretion of the
treating surgeon in guiding patient treatment.
Inclusion Criteria:
1. Patients undergoing primary total hip or knee arthroplasty with no history of prior
surgery
2. Patients undergoing revision hip or knee arthroplasty for septic or aseptic
indication.
Exclusion Criteria:
1. Patients undergoing second stage re-implantation surgery for PJI.
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