The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease

This aim of this research project is to determine if low to moderate level exercise can have
an impact on stress, fatigue, and quality of life for individuals diagnosed with a primary
immunodeficiency disease. Many individuals diagnosed with primary immunodeficiency disease
report chronic fatigue and/or pain, which can potentially limit their participation in
exercise and physical activities. Research shows that regular exercise can improve both
physical and mental health for individuals diagnosed with a chronic medical condition.
Exercise is a healthy and low-cost alternative to some medications, and may be an effective
addition to the treatment plan for many patients with primary immunodeficiency disease.
Research also suggests that low level exercise may be beneficial to immune function, while
intense, or prolonged exercise can be harmful. This 8-week study will compare participants
engaging in a semi-customized, home exercise program (exercise intervention group) to
participants performing normal activities (non-exercise control group). This study will track
stress, fatigue, and quality of life, using standardized questionnaires, journals, and
interviews. Weekly contact will be made with all participants throughout the 8 weeks of the
study. Individuals in the exercise group will be asked to complete up to 150 minutes of
exercise, per week, at the 11-14 rating of perceived exertion. Participants who are
randomized to the control group will continue their normal activities; they will also be
given the opportunity to participate in the exercise program at the end of the 8 week study.
To help assess the safety of a low to moderate level exercise program for individuals with
primary immunodeficiency disease, this research will track the number of infections,
non-planned medical visits, or increased medication usage during the study (compared to 8
weeks prior to the intervention). This research will help provide valuable information about
the safety and effectiveness of an exercise program for individuals with a primary
immunodeficiency disease.

Inclusion Criteria:

- 18 years of age or older.

- Physician diagnosis of a primary immunodeficiency disease (as evidenced by physician
letter or medical documentation/report)

- Willingness to participate in eight-week exercise program

Exclusion Criteria:

- Current participation in a structured exercise program for greater than 75 minutes per
week

- Any medical condition that prevents participation in a low to moderate level exercise
program (such as, but not limited to, uncontrolled asthma, unstable cardiac condition,
acute orthopedic injury which requires restricted activities)