Study to Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Participants With Staphylococcus Aureus Bacteremia Receiving Standard-of-Care (SOC) Antibiotics

Inclusion Criteria:

- Body mass index greater than or equal (>/=) 18 to less than or equal to ( kg/m^2

- At randomization, participants must have >/=1 blood culture or molecular diagnostic
that is positive for Staphylococcal aureus (S. aureus) collected in the previous 120
hours

- In the investigator's judgment, an expected treatment duration for S. aureus
intravenous infection with anti-staphylococcal SOC antibiotics >/= 4 weeks

Exclusion Criteria:

- The presence of an intravascular catheter that is not planned to be removed within 96
hours of study randomization

- S. aureus bacteremia associated with an intracardiac device and/or intravascular
prosthetic material (including hemodialysis access graft)

- In the investigator's judgement, S. aureus bacteremia involving infection of a
prosthetic joint or vertebral hardware

- In participants with cirrhosis, a Child-Pugh Score of Class B or C

- Known rifampicin-resistant S. aureus

- Anticipated receipt of a rifamycin class (excluding rifaxamin) antibiotic from Day 1
to study completion/discontinuation

- In the investigator's judgment, the need for emergent valve surgery at the time of
randomization or a high likelihood of cardiac surgery within 3 days after
randomization

- Polymicrobial bacteremia

- Participants with significant immune suppression

- Participants with evidence of liver disease

- History or presence of an abnormal electrocardiogram (ECG)

- Exposure to any biological therapy or investigational biological agent within 90 days
prior to the screening evaluation or have received any other investigational treatment
30 days prior to the screening evaluation