Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 5/6/2018 |
| Start Date: | February 13, 2017 |
| End Date: | February 2020 |
| Contact: | James E Ip, M.D |
| Email: | jei9008@med.cornell.edu |
| Phone: | 212 746 2158 |
Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological
mechanisms underlying PVC are sensitive to adenosine. Twenty subjects undergoing
clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for
PVCs will receive adenosine to learn if their arrhythmias are inducible similarly to
sustained ventricular tachycardia.
mechanisms underlying PVC are sensitive to adenosine. Twenty subjects undergoing
clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for
PVCs will receive adenosine to learn if their arrhythmias are inducible similarly to
sustained ventricular tachycardia.
The cellular mechanism of premature ventricular contractions (PVCs) is unknown. The
investigators have previously observed that 5% of patients in the investigators
electrophysiology laboratory with ventricular outflow tract PVCs have inducible sustained
ventricular tachycardia that behaves in a manner similar to patients who present clinically
with sustained ventricular tachycardia, i.e., sensitive to adenosine and triggered activity.
This suggests that outflow arrhythmias may be a continuum of a single mechanism. To further
determine the mechanism of frequent PVCs, the investigators will determine the effects of
pharmacologic agents administered prior to catheter ablation.
The investigators hypothesize that study subjects with ambient PVCs will have the
participants PVCs suppressed with exogenous adenosine.
The information from this study will elucidate the underlying cellular mechanism of this
common arrhythmia. Such knowledge could potentially lead to developing therapeutic targets.
investigators have previously observed that 5% of patients in the investigators
electrophysiology laboratory with ventricular outflow tract PVCs have inducible sustained
ventricular tachycardia that behaves in a manner similar to patients who present clinically
with sustained ventricular tachycardia, i.e., sensitive to adenosine and triggered activity.
This suggests that outflow arrhythmias may be a continuum of a single mechanism. To further
determine the mechanism of frequent PVCs, the investigators will determine the effects of
pharmacologic agents administered prior to catheter ablation.
The investigators hypothesize that study subjects with ambient PVCs will have the
participants PVCs suppressed with exogenous adenosine.
The information from this study will elucidate the underlying cellular mechanism of this
common arrhythmia. Such knowledge could potentially lead to developing therapeutic targets.
Inclusion Criteria:
1. Diagnosis of premature ventricular contractions (PVCs)
2. Scheduled to undergo an electrophysiology study with the intention of performing
cardiac ablation for the treatment of PVCs
3. Male or female between the ages of 18 and 70 years
4. Capable of giving informed consent
Exclusion Criteria:
1. Any structural heart disease
2. Coronary artery disease (≥ 70% stenosis)
3. Current treatment with anti-arrhythmic drugs
4. Pregnant
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