CLEAR Sepsis Clinical Study

Venous Blood Lactate Groups

Inclusion Criteria:

- ≥ 18 years of age at the time of enrollment

- Any combination of acute symptoms and signs that the treating ED physician, after
initial history and physical examination, attributes to a systemic infection

- ED Physician confirms likely hospital admission (> 50%) due to suspicion of infection

- ED Physician confirms intention to order both blood cultures and venous blood lactate
levels

- Ability to enroll patient and begin ClearSight™ monitoring within three (3) hours of
ED presentation

Exclusion Criteria:

- Initial venous blood lactate measured > 3 hours after ED arrival

- Pre-existing infection for which patient is being treated with antibiotics as an
outpatient

- Prisoners

- Pregnant women

- Any previous medical condition with life expectancy of < 3 months (patients with ESRD
and heart failure are not excluded)

- DNR or comfort care order preexisting to ED visit or established in the ED

- Palliative care or hospice consult in the ED

- Known severe aortic insufficiency

- Known history of Raynaud's disease

- Poor follow-up candidate in the opinion of the Investigator

- Current or planned enrollment in an investigational trial that in the opinion of the
Investigator may significantly affect hemodynamic data collection.

Control Sepsis Mimic

Inclusion Criteria:

- ≥18 years of age at the time of enrollment

- Presents to the ED with a chief complaint consistent with a minor infection (upper
respiratory infection, soft tissue infection, viral infection) or an asthma or COPD
exacerbation on whom the treating physician is not ordering labs for blood cultures or
lactate levels

- Ability to enroll patient and begin ClearSight™ monitoring within three (3) hours of
ED presentation.

Exclusion Criteria:

- Pre-existing infection for which patient is being treated with antibiotics as an
outpatient

- Prisoners

- Pregnant women

- Any previous medical condition with life expectancy of < 3 months (patients with ESRD
and heart failure are not excluded)

- DNR or comfort care order preexisting to ED visit or established in the ED

- Palliative care or hospice consult in the ED

- Known severe aortic insufficiency

- Known history of Raynaud's disease

- Poor follow-up candidate in the opinion of the Investigator

- Current or planned enrollment in an investigational trial that in the opinion of the
Investigator may significantly affect hemodynamic data collection.

- Treating physician is planning on ordering either a lactate or blood cultures on the
patient.