Myeloid to Adipocyte Transdifferentiation in Human Cells
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 100 |
| Updated: | 10/18/2018 |
| Start Date: | March 2016 |
| End Date: | December 2020 |
| Contact: | Kathleen M Gavin, PhD |
| Email: | kathleen.gavin@ucdenver.edu |
| Phone: | 303-724-7472 |
In order to design new programs to help prevent weight gain, promote successful and
sustainable weight loss, and help treat diseases related to obesity, the investigators need a
better understanding of why accumulating fat in certain regions of the body is bad for
health. It is known that not all fat cells are the same, but it was recently discovered that
some fat cells may arise from stem cells that come from the bone marrow (bone marrow
progenitors), a previously unrecognized origin. This discovery has been paradigm shifting,
because dogma has long held that all white fat cells arise from fat tissue resident
mesenchymal stem cells. This is also important because fat cells arising from the bone marrow
lineage may be linked to worse health outcomes. The aim of this study is to determine if
cells that were not previously believed to contribute to fat generation in humans are indeed
capable of becoming fat cells. To answer this question the investigators will take samples of
cells from the blood and the fat tissue of younger and older men and women, isolate the cells
that came from the bone marrow and grow them in culture to determine if they will turn into
fat cells. The results of this investigation may reveal potential mechanistic targets for
future therapies to reduce the negative health outcomes associated with obesity related
chronic diseases.
sustainable weight loss, and help treat diseases related to obesity, the investigators need a
better understanding of why accumulating fat in certain regions of the body is bad for
health. It is known that not all fat cells are the same, but it was recently discovered that
some fat cells may arise from stem cells that come from the bone marrow (bone marrow
progenitors), a previously unrecognized origin. This discovery has been paradigm shifting,
because dogma has long held that all white fat cells arise from fat tissue resident
mesenchymal stem cells. This is also important because fat cells arising from the bone marrow
lineage may be linked to worse health outcomes. The aim of this study is to determine if
cells that were not previously believed to contribute to fat generation in humans are indeed
capable of becoming fat cells. To answer this question the investigators will take samples of
cells from the blood and the fat tissue of younger and older men and women, isolate the cells
that came from the bone marrow and grow them in culture to determine if they will turn into
fat cells. The results of this investigation may reveal potential mechanistic targets for
future therapies to reduce the negative health outcomes associated with obesity related
chronic diseases.
Inclusion Criteria:
- Men and women age 21-40 y or 55-100 y;
- Older women will be postmenopausal who are at least 12 months past the final menstrual
period (FMP);
- Young women will be premenopausal and eumenorrheic, not on hormonal contraceptive
therapy;
- Body Mass Index (BMI) 22-35 kg/m2;
- Non-active to moderately active (vigorous exercise ≤ 3 days/wk lasting < 30 min).
Exclusion Criteria:
- Immunosuppression therapy;
- On blood thinners, aspirin, or NSAIDs that cannot be withheld for the biopsy;
- Prior history of allergies to local anesthetics;
- Current use of hormones, or glucose lowering medication;
- Currently engaged in a vigorous exercise or diet program;
- Currently gaining or losing weight or using weight loss drugs;
- Type 2 diabetes (past/current diagnosis or treatment);
- Diagnosis of uncontrolled metabolic disorders (e.g., thyroid);
- History of severe obesity BMI ≥ 40 or significant weight loss (≥ 50 lbs);
- Postmenopausal - hormonal menopausal therapy use currently or in the previous 6
months;
- Premenopausal - irregular menstrual cycles defined as 2 or more missed cycles in the
previous year, pregnant or planning to become pregnant during the study timeline
(urine pregnancy test will be performed before DEXA [dual energy x-ray absorptiometry]
scan is completed).
We found this trial at
1
site
13001 E 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
(303) 724-5000
Phone: 303-724-7472
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
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