Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/15/2019 |
| Start Date: | August 1, 2016 |
| End Date: | January 31, 2018 |
Comparison of Methohexital With Propofol for Anesthetic Induction in Patients Treated With an Antagonist of the Renin-Angiotensin System.
Patient undergoing general anesthesia in elective surgery will be assigned to receive either
methohexital or propofol general anesthesia. Hypotensive events during the first 15 minutes
of induction will be compared between the groups to ascertain which drug is less likely to
cause a hypotensive event.
methohexital or propofol general anesthesia. Hypotensive events during the first 15 minutes
of induction will be compared between the groups to ascertain which drug is less likely to
cause a hypotensive event.
Patients taking angiotensin converting-enzyme inhibitors (ACEIs) or angiotensin receptor
blockers (ARBs) are susceptible to hypotensive events during general anesthesia. The purpose
of this study is to determine if the use of either methohexital or propofol general
anesthesias is more likely to result in hypotensive events in these patients during their
induction. Hemodynamic metrics like blood pressure, mean arterial pressure, and heart rate
will be monitored during the induction process, under both drugs, for use as the main
metrics, as well as the need for vasopressors in response to patient hypotension.
blockers (ARBs) are susceptible to hypotensive events during general anesthesia. The purpose
of this study is to determine if the use of either methohexital or propofol general
anesthesias is more likely to result in hypotensive events in these patients during their
induction. Hemodynamic metrics like blood pressure, mean arterial pressure, and heart rate
will be monitored during the induction process, under both drugs, for use as the main
metrics, as well as the need for vasopressors in response to patient hypotension.
Inclusion Criteria:
- treated for at least 6 weeks with ACEIs or ARB
- undergoing elective surgery under general endotracheal anesthesia
- ASA Physical Class I or II
Exclusion Criteria:
- BMI >45kg/m^2
- taking both ACEI and ARB
- history of difficult intubation in the past
- require rapid sequence induction and intubation
- uncontrolled baseline blood pressure (SBP>180mmHg or DBP >110 mmHg) at anesthesia
preoperative clinic visit
- contraindication to the use of propofol or methohexital
- significant coronary artery disease
- history of systolic heart failure
- history of renal failure (creatine level >2 mg/dL)
We found this trial at
1
site
500 University Dr
Hershey, Pennsylvania 17033
Hershey, Pennsylvania 17033
(717) 531-6955
Phone: 717-531-8521
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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