Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
| Status: | Terminated |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 4/17/2018 |
| Start Date: | May 1, 2017 |
| End Date: | March 23, 2018 |
The investigators objective is to assess the utility of renal biomarkers in predicting renal
recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
Tissue biomarkers of renal injury may provide a real-time indication of renal function and
the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO.
In these patients, traditional markers of kidney function (urine output and serum Creatinine
level) do not accurately represent renal function.
recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO).
Tissue biomarkers of renal injury may provide a real-time indication of renal function and
the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO.
In these patients, traditional markers of kidney function (urine output and serum Creatinine
level) do not accurately represent renal function.
Inclusion Criteria:
- age more than 18 years
- refractory or advanced cardiogenic shock prior to institution of VA-ECMO
Exclusion Criteria:
- History of chronic kidney disease prior to cardiogenic shock, as defined by estimated
glomerular filtration rate (GFR) less than 60 mL per min
- Cognitive impairment
- Pregnant women
- patient or surrogate is not fluent in English
- Long-term immunosuppression
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