Effects of Altitude on Single-Breath Diffusing Capacity for Carbon Monoxide
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 20 - 80 |
| Updated: | 8/9/2018 |
| Start Date: | August 10, 2017 |
| End Date: | August 2018 |
Effects of Altitude on Single-Breath Diffusing Capacity for Carbon Monoxide in Normal Subjects and Chronic Obstructive Pulmonary Disease
The purpose of this study is to further understand the effects of altitude on the physiology
of gas exchange in the pulmonary microcirculation in normal subjects and in people with
chronic obstructive pulmonary disease (COPD) measured as the single-breath diffusing capacity
for carbon monoxide (DLCOsb). The study will determine a mathematical formula to allow for
altitude corrections in both study populations to be used clinically in pulmonary labs.
of gas exchange in the pulmonary microcirculation in normal subjects and in people with
chronic obstructive pulmonary disease (COPD) measured as the single-breath diffusing capacity
for carbon monoxide (DLCOsb). The study will determine a mathematical formula to allow for
altitude corrections in both study populations to be used clinically in pulmonary labs.
The DLCOsb is one of the most common and widely tests clinically used across the world in
pulmonary function laboratories to assess gas exchange from the lung to hemoglobin in the
pulmonary circulation. This test is used in the differential diagnosis of respiratory related
symptoms, to grade the degree of severity in lung disease, and to objectively monitor the
progression of disease or the response to therapies. Therefore, it is important to have
standard methods of performing and interpreting this test.This is a prospective study,
collecting data from subjects at different simulated altitudes. The study hypothesis is that
increasing altitude will increase the DLCOsb in a predictable manner that will allow for
mathematical corrections to be applied for uniform interpretation in pulmonary labs at
differing altitudes.
pulmonary function laboratories to assess gas exchange from the lung to hemoglobin in the
pulmonary circulation. This test is used in the differential diagnosis of respiratory related
symptoms, to grade the degree of severity in lung disease, and to objectively monitor the
progression of disease or the response to therapies. Therefore, it is important to have
standard methods of performing and interpreting this test.This is a prospective study,
collecting data from subjects at different simulated altitudes. The study hypothesis is that
increasing altitude will increase the DLCOsb in a predictable manner that will allow for
mathematical corrections to be applied for uniform interpretation in pulmonary labs at
differing altitudes.
Inclusion Criteria:
- Ages 20- 80 years
- Subjects must be either healthy or have been diagnosed with COPD
Exclusion Criteria:
- Anemia (hemoglobin < 10.0 g/dL)
- Carboxyhemoglobin > 3%
- Active smoking
- Heart disease or heart failure
- Pulmonary hypertension
- COPD exacerbation
- Pneumothroax within 6 months
- Bullous emphysema on chest imaging (Chest X-ray or CT)
- Supplemental oxygen use
- Diabetes mellitus
- Alcohol dependence
- Non-English speaking
We found this trial at
1
site
5121 S Cottonwood St
Murray, Utah 84157
Murray, Utah 84157
(801) 507-7000
Phone: 801-507-4700
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