An Open-label, Randomized, 3-period Crossover Study to Evaluate Sumatriptan Pharmacokinetics for a TREXIMA™ (Sumatriptan Succinate / Naproxen Sodium) Tablet Followed by IMITREX® (Sumatriptan Succinate)

An open-label, randomized, 3-period crossover study to evaluate sumatriptan pharmacokinetics
for a TREXIMA™ (sumatriptan succinate / naproxen sodium) Tablet followed by IMITREX®
(sumatriptan succinate) Injection 4mg administered using the IMITREX STATdose System® and a
TREXIMA tablet followed by IMITREX® (sumatriptan succinate) Injection 6mg administered using
the IMITREX STATdose System® compared with an IMITREX Tablet 100mg followed by an IMITREX
Tablet 100mg.

Inclusion Criteria:

- Healthy adult males and females between 18 and 55 years of age, inclusive. Healthy
subjects are defined as individuals who are free from clinically significant illness
or disease as determined by their medical history, physical examination, laboratory
studies and other tests.

- Female subjects of non-childbearing potential

- Any subject taking oral contraceptives has been on a stable regimen for at least 2
months prior to screening.

- BMI: 20-30 kg/m2, inclusive.

- Subject is willing and able to provide written informed consent.

Exclusion Criteria:

- Subjects who suffer from migraine attacks.

- Subject has confirmed or suspected ischemic heart disease; angina pectoris, history of
myocardial infarction, documented silent ischemia, Prinzmetal's angina-coronary
vasospasm, signs, or symptoms consistent with any of the above.

- Subject has evidence or history of ischemic abdominal syndromes, peripheral vascular
disease or Raynaud's syndrome.

- Subject has cardiac arrhythmias requiring medication or a history of a clinically
significant electrocardiogram abnormality that, in the investigator's opinion,
contraindicates participation in this study.

- Subject has a history of cerebrovascular pathology including stroke and/or transient
ischemic attacks.

- Subject has a history of congenital heart disease.

- Subject has hypertension at screening.

- Subject, in the investigator's opinion, is likely to have unrecognized cardiovascular
or cerebrovascular disease.

- Subject has a history of epilepsy or structural brain lesions which lower the
convulsive threshold or treated with an antiepileptic drug for seizure control within
5 years prior to screening.

- History of impaired hepatic or renal function.

- Subject is currently taking or has taken in the previous 4 weeks, herbal preparations
containing St. John's Wort.

- Use of other prescription or non-prescription drugs, vitamins, herbal and dietary
supplements, within 7 days prior to the first dose of study medication.

Note: Excluded from this list are: acetaminophen at doses of less than or equal to 2 grams
per day and contraceptives.

- Subject has a hypersensitivity, intolerance, or contraindication to the use of
sumatriptan or naproxen sodium or any of their components or any other 5-HT1 receptor
agonist.

- Subject has a history of any gastrointestinal surgery that specifically indicates a
past history of bleeding, ulceration or perforation.

- Subject has a history of gastric bypass or stapling surgery.

- Subject has a history of GI ulceration in the past six months or gastrointestinal
bleeding in the past year.

- Subject has a history of inflammatory bowel disease.

- Treatment with an investigational drug within 30 preceding the first dose of study
medication.

- Positive serum beta-human chorionic gonadotropin test -females.

- Pregnant, actively trying to become pregnant or breast-feeding.

- Subjects with a history of drug or alcohol abuse.

- History of regular alcohol consumption exceeding 7 drinks per week for females or 14
drinks per week for men within 6 months of screening.

- Positive urine drug screen including alcohol at screening.

- Donation of blood in excess of 500 mL within 56 days prior to first dose of study
medication.

- Subjects who smoke more than 10 cigarettes per day.

- History of sensitivity to heparin, heparin-induced thrombocytopenia or sensitivity to
any of the study medications or components thereof.