Neuroendocrine Response to Oral Alcohol Administration
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 1/19/2019 |
| Start Date: | September 8, 2016 |
| End Date: | June 30, 2018 |
This study proposes to examine both the peripheral and central nervous system responses when
light social drinkers and binge/heavy social drinkers are exposed to oral ethanol. The
findings will provide a greater understanding of the brain mechanisms (cerebral blood flow
and functional connectivity) underlying the association between stress, cortisol release,
heart rate variability, alcohol craving, and alcohol stimulant and sedative effects. This
knowledge could be significant in developing new therapies for the treatment of alcoholism.
light social drinkers and binge/heavy social drinkers are exposed to oral ethanol. The
findings will provide a greater understanding of the brain mechanisms (cerebral blood flow
and functional connectivity) underlying the association between stress, cortisol release,
heart rate variability, alcohol craving, and alcohol stimulant and sedative effects. This
knowledge could be significant in developing new therapies for the treatment of alcoholism.
Inclusion Criteria:
- Binge/Heavy Social Drinkers (HSD): has never met DSM-IV criteria for alcohol or
substance dependence; regular alcohol use over the past year of at least 10 drinks per
week, including at lease one occasion per week consuming >4 drinks (males) or >3
drinks (females).
- Able to read and write English.
- Light Social Drinkers (LSD): has never met DSM-IV criteria for alcohol or substance
dependence; regular alcohol use over the past year of 1-3 drinks per occasion, 1-3
times weekly, with no more than one occasion per month of drinking >4 drinks (male) or
>3 drinks (females) (King et al., 2002).
- Do not meet criteria for any Axis I DSM-IV psychiatric diagnoses except for
individuals with a past diagnosis of Post-Traumatic Stress Disorder, Major Depressive
Disorder, or Obsessive Compulsive Disorder; and provide negative urine toxicology
screens during initial appointments and at admission for IV/fMRI sessions.
- Body Mass Index between 20-28.
- No current or former nicotine dependence.
Exclusion Criteria:
- Meet current criteria for dependence on any psychoactive substance, excluding
caffeine.
- Current or past history of alcohol dependence or abuse.
- Any current use of opiates or past history of opiate abuse/dependence.
- Current use of any psychoactive drugs, including anxiolytics, antidepressants,
naltrexone or antabuse.
- Any psychotic disorder or current psychiatric symptoms requiring specific attention,
including need for psychiatric medications for current major depression and anxiety
disorders.
- Any significant current medical condition such as neurological, cardiovascular,
endocrine, renal, liver, thyroid pathology; subjects on medications for any medical
condition will be excluded.
- Peri and post menopausal women, and those with hysterectomies.
- Pregnant and lactating women will be excluded.
We found this trial at
1
site
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
Click here to add this to my saved trials
