Direct Peritoneal Resuscitation in Gastroschisis
Status: | Recruiting |
---|---|
Conditions: | Women's Studies |
Therapuetic Areas: | Reproductive |
Healthy: | No |
Age Range: | Any |
Updated: | 8/3/2018 |
Start Date: | February 1, 2018 |
End Date: | December 2019 |
Contact: | Bavana Ketha, MD |
Email: | bketha@uams.edu |
Phone: | 501-364-2943 |
Gastroschisis is a clinical condition characterized by a defect in the normal development of
the abdominal wall. The defect is present to the right of the umbilicus leading to in utero
bowel evisceration and exposure to amniotic fluid. Prolonged exposure to amniotic fluid may
lead to inflammatory changes and damage to the exteriorized bowel. After birth and prior to
operation, the usual treatment consists of covering the bowel with impermeable plastic bag to
prevent additional fluid losses and bowel desiccation. Subsequent operative intervention
occurs either in the operating room or in the neonatal intensive care unit. Two surgical
options include primary closure of the abdomen or placement of a silastic silo followed by
subsequent closure several days later as a staged procedure. The main reason the abdominal
wall is not closed initially is due to fear of abdominal compartment syndrome, a condition
caused by high intra-abdominal pressures leading to respiratory and circulatory compromise.
The key points of the initial surgery involve examining the intestine for any signs of
atresia, bowel compromise, and either placement of the bowels back into the abdomen or a
spring loaded silo.
the abdominal wall. The defect is present to the right of the umbilicus leading to in utero
bowel evisceration and exposure to amniotic fluid. Prolonged exposure to amniotic fluid may
lead to inflammatory changes and damage to the exteriorized bowel. After birth and prior to
operation, the usual treatment consists of covering the bowel with impermeable plastic bag to
prevent additional fluid losses and bowel desiccation. Subsequent operative intervention
occurs either in the operating room or in the neonatal intensive care unit. Two surgical
options include primary closure of the abdomen or placement of a silastic silo followed by
subsequent closure several days later as a staged procedure. The main reason the abdominal
wall is not closed initially is due to fear of abdominal compartment syndrome, a condition
caused by high intra-abdominal pressures leading to respiratory and circulatory compromise.
The key points of the initial surgery involve examining the intestine for any signs of
atresia, bowel compromise, and either placement of the bowels back into the abdomen or a
spring loaded silo.
Inclusion Criteria:
• Diagnosis of Gastroschisis
Exclusion Criteria:
- Primary gastroschisis repair
- Existing severe lactic acidosis with pH < 6.8
- Encapsulating Peritoneal Sclerosis
- Vanishing Gastroschisis
- Severe hypotension or sepsis that may be associated with acute renal failure
- Hepatic failure
- Known or strongly suspected inborn errors in metabolism
- Significant cardiac disorders
- Any other condition, that, in the opinion of the investigator, might interfere with
the safe conduct of the study or place the subject at increased risk
We found this trial at
1
site
1 Children's Way
Little Rock, Arkansas 72202
Little Rock, Arkansas 72202
(501) 364-1100
Phone: 501-364-2943
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
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