Chronic Effects of Fats on Satiety & Energy Needs
| Status: | Terminated |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 55 |
| Updated: | 8/5/2018 |
| Start Date: | October 3, 2017 |
| End Date: | May 24, 2018 |
Chronic Effects of Fats on Satiety and Energy Expenditure
The purpose of this study is to evaluate the effect of dietary fat on satiety (the experience
of fullness between one meal and the next) and energy metabolism over an extended period of
time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is
unclear. The investigators will use a controlled setting for the studies. They want to know
if the source of dietary fat alters satiety, satiety hormones, and energy expenditure
responses after consuming different diets.
of fullness between one meal and the next) and energy metabolism over an extended period of
time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is
unclear. The investigators will use a controlled setting for the studies. They want to know
if the source of dietary fat alters satiety, satiety hormones, and energy expenditure
responses after consuming different diets.
This work will address the interaction of obesity and dietary fatty acids in regulating
satiety and energy metabolism. The primary objective is to determine the effects of chronic
intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis
and energy utilization in healthy individuals. The investigators hypothesize that unsaturated
fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty
acid binding protein polymorphisms are associated with reduced energy expenditure in response
to dietary fat intake.
satiety and energy metabolism. The primary objective is to determine the effects of chronic
intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis
and energy utilization in healthy individuals. The investigators hypothesize that unsaturated
fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty
acid binding protein polymorphisms are associated with reduced energy expenditure in response
to dietary fat intake.
Inclusion Criteria:
- body mass index between 25.0-34.9 kg/m2
- free of major diagnosed, untreated medical conditions
- non-smoking or use of other tobacco products, including e-cigarettes
- not taking steroid-based medications
- not planning to or currently attempting to gain or lose weight
- willing to comply with study demands
- low intake of long chain omega-3 fatty acids (<0.10 g/d) or willing to reduce intake
for 6 weeks prior to starting the study
Exclusion Criteria:
- diagnosed eating disorders
- diabetes (blood sugar ≥ 126 mg/dl)
- hypertension (systolic > 160 mmHg or diastolic > 100 mmHg)
- diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases
- currently pregnant or planning to become pregnant, or lactating
- taking medications known to affect appetite, blood lipids, body composition, body
weight, or food intake (appetite control drugs, steroids, antidepressants)
We found this trial at
1
site
Grand Forks, North Dakota 58202
Phone: 701-795-8386
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