A Study To Evaluate The Effect Of WELLBUTRIN XL On Intraocular Pressure

Inclusion Criteria:

- Healthy males or females.

- Non-smokers

- Agree to remain in the clinic for the time defined in the protocol.

- Normal ECG.

Exclusion Criteria:

- Any serious medical disorder or condition.

- Any history of an endocrine disorder.

- Any clinically significant laboratory abnormality.

- History of psychiatric illness.

- Any history of suicidal attempts or behavior.

- Risk factors for precipitation of angle closure glaucoma or elevated IOP.

- Inability to refrain from use of contact lenses during the study days, if correction
is required.

- Self-administered Beck Depression Inventory II scale total score greater than 9, and a
suicide question score of greater than zero.

- Current or past history of seizure disorder or brain injury (traumatic or
disease-related); or any condition which, in the opinion of the investigator,
predisposes to seizure - Women having a positive serum HCG pregnancy test at
screening, a positive urine pregnancy test before admission to the Unit during the
in-house periods, who are not willing to use acceptable methods of contraception or
who are lactating or planning to become pregnant within the three months following the
screening visit.