Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have
developed a laboratory model to investigate the effects of potential treatment medications on
cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non
treatment-seeking cannabis smokers. In this study, the investigators are interested in
testing how lorcaserin influences the effects of cannabis in a human laboratory model of
cannabis use.

Inclusion Criteria:

- Current cannabis use

- Able to give informed consent and perform study procedures

- Women practicing an effective form of birth control

- English speaking

Exclusion Criteria:

- Presence of any clinically significant medical diagnoses

- History of heart disease and cardiac risk factors, severe chronic obstructive
pulmonary disease, uncontrolled hypertension, or diabetes

- Current parole or probation

- Certain psychiatric diagnoses

- Current pregnancy or lactation