Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease

Target Population and Enrollment. The study will recruit and consent 300 patients from our
Occupational Medicine and Interstitial Lung Disease Clinics at National Jewish Health who
have been referred for evaluation of chronic lung conditions. The healthy control group will
comprise 300 volunteers who are at least 18 years of age, have no history of pre-existing
lung disease, and report no respiratory illness in the four weeks preceding enrollment.
Inclusion criteria for the group with chronic lung disease will include physician diagnosis
of a chronic lung condition (e.g. bronchiolitis, pulmonary fibrosis, asthma, coal mine dust
lung disease, asbestosis), and age ≥18 years. Exclusion criteria will include recent
myocardial infarction, stroke, eye surgery, chest/abdominal surgery (within past month),
known thoracic, aortic, or cerebral aneurysm, or uncontrolled hypertension. Study
participation will consist of one visit that will last between 90-120 minutes. The chronic
lung disease group will fill out the informed consent and complete both LCI testing and
spirometry. The healthy control group will complete informed consent, a brief questionnaire,
LCI testing, and spirometry.

Inclusion Criteria:

- physician diagnosis of a chronic lung condition (e.g. bronchiolitis, pulmonary
fibrosis, asthma, coal mine dust lung disease, asbestosis), and age ≥18 years.

The healthy control group will comprise 300 volunteers who are at least 18 years of age,
have no history of pre-existing lung disease, and report no respiratory illness in the four
weeks preceding enrollment

Exclusion Criteria:

- Exclusion criteria will include recent myocardial infarction, stroke, eye surgery,
chest/abdominal surgery (within past month), known thoracic, aortic, or cerebral
aneurysm, or uncontrolled hypertension.