Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis

The purpose of this study is:

1. To determine the efficacy of photodynamic therapy (PDT) in the treatment of seborrheic
dermatitis.

2. To determine how PDT alters the skin microbiome in subjects with seborrheic dermatitis
before and after treatment.

3. To determine how PDT alters sebum secretion rates in subjects with seborrheic dermatitis
before and after treatment.

The researchers hypothesize that PDT will be efficacious in the treatment of seborrheic
dermatitis.

Inclusion Criteria:

- Healthy subjects 18 years or older with seborrheic dermatitis of the face will be
included.

Exclusion Criteria:

- Subjects who are taking systemic corticosteroids (at doses of prednisone greater than
or equal to 5 mg daily), antibiotics (PO, IM or IV) or using topical anti- fungals,
steroids, antibiotics, permethrin, or calcineurin inhibitors within 2 weeks prior to
the study will be excluded.

- The exclusion criteria will also include the presence of other untreated inflammatory
conditions (such as lupus, atopic dermatitis, or psoriasis) or untreated malignancies
on the face (including skin cancers such as basal cell carcinoma, squamous cell
carcinoma and melanoma).

- Any subjects with known or suspected hypersensitivity to any constituent of the study
medication or a history of photosensitivity due to conditions such as lupus
erythematosus and porphyria will be excluded.

- Subjects who have had photodynamic therapy (PDT) to the face for any reason within the
past year will be excluded as well.

- Adults unable to consent, individuals under the age of 18, pregnant or breastfeeding
women and prisoners will be excluded from the study.