High Resolution Micro OCT Imaging
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 2/7/2019 |
| Start Date: | April 15, 2016 |
| End Date: | December 31, 2020 |
| Contact: | Heather Hathorne, PhD |
| Email: | hhathorne@peds.uab.edu |
| Phone: | 205-638-9568 |
Imaging of Human Epithelial Airway Using a High Resolution Micro OCT Catheter (Functional Anatomic Imaging of CF Patients With Early Lung Disease Using Micro OCT)
The purpose of this study is to learn about using the imaging to make images of the lungs and
nose with the long-term goal of the research leading to potential treatments and new
therapies for patients with cystic fibrosis.
nose with the long-term goal of the research leading to potential treatments and new
therapies for patients with cystic fibrosis.
Lung Disease is the predominate cause of morbidity and mortality in patients with cystic
fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order
to reveal the features that may lead to the onset of progressive lung disease. Discerning the
nature of the CF defect could resolve longstanding controversy and result in a new
therapeutic opportunity that may address pathophysiology. Recently the investigators have
developed an innovative technology, termed 1-µm resolution optical coherence tomography
(µOCT), which enables real-time cross-sectional microscopy of the functional epithelial
surface of living airways.
fibrosis (CF). A better understanding of the primary pathogenesis of CF is essential in order
to reveal the features that may lead to the onset of progressive lung disease. Discerning the
nature of the CF defect could resolve longstanding controversy and result in a new
therapeutic opportunity that may address pathophysiology. Recently the investigators have
developed an innovative technology, termed 1-µm resolution optical coherence tomography
(µOCT), which enables real-time cross-sectional microscopy of the functional epithelial
surface of living airways.
THE INCLUSION CRITERIA:
- Patients diagnosed with CF or healthy normal controls with no respiratory disease
- Patients must be over the age of 18 but less than 70
- Patient must be able to give informed consent
THE EXCLUSION CRITERIA:
- Patients with recent respiratory infection requiring antibiotics or corticosteroids in
the last 4 weeks (excluding routine perioperative antibiotics)
- Patients with major sinus surgery that will alter the nasal anatomy and preclude
imaging of the nares
- Any condition that in the opinion of the investigator will alter the safety of pilot
testing in the operating room
- Female subjects who are pregnant
We found this trial at
1
site
1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
Principal Investigator: Rowe Steven, MD
Phone: 205-638-9568
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
Click here to add this to my saved trials
