Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression



Status:Completed
Conditions:Depression, Depression
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:8/30/2017
Start Date:April 2014
End Date:July 2017

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Depressed patients miss a night of sleep (Wake Night), then sleep at predetermined times
ending at their desired sleep time. Beginning the morning following their Wake Night,
patients sit in front of a bright light, continuing morning bright light and specified sleep
time for six weeks with weekly visits measuring depressive symptoms.

Nonpsychotic, nonbipolar, physically healthy depressed patients keep sleep, mood and energy
logs for a week, complete the Morningness-Eveningness Questionnaire (measuring "morningness"
and "eveningness") and determine the time patients want to sleep. Patients then miss a night
of sleep and subsequently are allowed later and later sleep times until patients are sleeping
at their desired time. Beginning the morning following their Wake Night, patients sit in
front of bright lights at their intended wake-up time for the next six weeks and once their
allowed sleep time is their intended sleep time, patients also continue to only be allowed to
sleep between those times (e.g., 11 p.m. to 7 a.m.). Daily sleep, energy and mood logs and
activity monitoring are maintained throughout with weekly clinician ratings. In additional,
daily telephone check ins occur during the first week following the Wake Night both to be
sure the patient is following the protocol and to obtain symptom ratings. Saliva to be
measured for melatonin is collected prior to and following sleep adjustment.

Inclusion Criteria:

- major depressive disorder or persistent depressive disorder or unspecified depressive
disorder

- physically healthy

- patients over age 60 need primary care physician's approval, electrocardiogram and
Mini Mental Status Examination

Exclusion Criteria:

- medically unstable condition

- bipolar disorder

- current (past six months) substance use disorder

- significant suicide risk

- need for hospitalization

- history of psychosis
We found this trial at
1
site
1051 Riverside Dr
New York, New York 10032
646-774-5000
New York State Psychiatric Institute The New York State Psychiatric Institute (NYSPI), established in 1895,...
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New York, NY
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