Adverse Neurogenic Actions of Dietary Salt
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - 75 |
| Updated: | 4/17/2018 |
| Start Date: | April 2016 |
| End Date: | April 2021 |
| Contact: | William B Farquhar, PhD |
| Email: | wbf@udel.edu |
| Phone: | 302-831-6178 |
Excess dietary salt increases the risk for cardiovascular events, even in people that are not
hypertensive. There is some evidence that excess dietary salt exaggerates blood pressure and
sympathetic nervous system responses to various perturbations and increases blood pressure
variability. This proposal will examine the effects of low, medium, and high salt diets on
cardiovascular reactivity and blood pressure variability.
hypertensive. There is some evidence that excess dietary salt exaggerates blood pressure and
sympathetic nervous system responses to various perturbations and increases blood pressure
variability. This proposal will examine the effects of low, medium, and high salt diets on
cardiovascular reactivity and blood pressure variability.
Excess dietary salt causes target organ damage and increases the risk for adverse
cardiovascular (CV) events independent of blood pressure (BP). Recent data in salt-resistant,
normotensive rodents suggest that high dietary salt enhances the excitability or gain of
sympathetic circuits, exaggerates sympathetic and CV responses to various stimuli, and
increases BP variability (BPV). There are limited data regarding the impact of dietary salt
intake on sympathetic nerve activity (SNA) and CV function in salt-resistant humans as well
as the underlying mechanisms contributing to these adverse effects. The long-term goal is to
determine how dietary salt adversely affects BP regulation and CV health. The objective of
this proposal is to comprehensively evaluate the impact of dietary salt intake on SNA and CV
reactivity and BPV in normotensive humans. The investigators have 2 specific aims: 1) Aim 1
will test the hypothesis that high dietary salt increases SNA and CV reactivity in
normotensive adults, 2) Aim 2 will test the hypothesis that high dietary salt increases BPV
in normotensive adults. The expected outcome is to demonstrate that dietary salt loading
increases CV reactivity and BPV through a sympathetic nervous system mechanism that
originates in the brain. The proposed research is significant, as these studies will provide
empirical evidence that dietary salt intake impacts neurohumoral control of the circulation
in salt-resistant humans. The proposed research is innovative because it will identify a
novel neurogenic action of dietary salt in human CV regulation.
cardiovascular (CV) events independent of blood pressure (BP). Recent data in salt-resistant,
normotensive rodents suggest that high dietary salt enhances the excitability or gain of
sympathetic circuits, exaggerates sympathetic and CV responses to various stimuli, and
increases BP variability (BPV). There are limited data regarding the impact of dietary salt
intake on sympathetic nerve activity (SNA) and CV function in salt-resistant humans as well
as the underlying mechanisms contributing to these adverse effects. The long-term goal is to
determine how dietary salt adversely affects BP regulation and CV health. The objective of
this proposal is to comprehensively evaluate the impact of dietary salt intake on SNA and CV
reactivity and BPV in normotensive humans. The investigators have 2 specific aims: 1) Aim 1
will test the hypothesis that high dietary salt increases SNA and CV reactivity in
normotensive adults, 2) Aim 2 will test the hypothesis that high dietary salt increases BPV
in normotensive adults. The expected outcome is to demonstrate that dietary salt loading
increases CV reactivity and BPV through a sympathetic nervous system mechanism that
originates in the brain. The proposed research is significant, as these studies will provide
empirical evidence that dietary salt intake impacts neurohumoral control of the circulation
in salt-resistant humans. The proposed research is innovative because it will identify a
novel neurogenic action of dietary salt in human CV regulation.
Inclusion Criteria:
- normal blood pressure
- men, Women, minorities
- ECG within normal limits
- screening blood panel within normal limits
Exclusion Criteria:
- high blood pressure (>140/90 mmHg)
- history of cardiovascular disease
- history of cancer
- history of diabetes
- history of kidney disease
- obesity (BMI > 30 kg/m2)
- smoking or tobacco use
- current pregnancy
- nursing mothers
- communication barriers
We found this trial at
1
site
Newark, Delaware 19716
Principal Investigator: William B Farquhar, PhD
Phone: 302-831-7343
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