HCR vs. CABG Study

Currently, it is not clear how the outcomes of hybrid coronary revascularization (HCR)
compare with other treatments. The purpose of the study is to find out if HCR and coronary
artery bypass grafting (CABG) procedure outcomes are similar. HCR is a combination of surgery
and catheter procedures to open up clogged heart arteries. CABG is a surgical procedure to
open up clogged heart arteries.

This study will collect information about the medical care participants receive during their
planned procedure. No new testing or procedures will be done. Participants will have only the
tests or procedures already planned by their doctor. The investigators will look at how well
participants do after the procedure by assessing the outcomes of interest 30 days after
surgery and, potentially, one year after surgery (funding dependent).

Inclusion Criteria:

- Able to give informed consent

- Have multi-vessel coronary artery disease (CAD) involving the Left Anterior Descending
(LAD) artery

- Have a clinical indication for revascularization

- Are a candidate for either HCR or CABG or both

- Anatomy suitable for HCR shall include

1. Multi-vessel CAD involving the LAD and/or

2. LAD disease and involvement of a major diagonal artery, both of which require
revascularization

Exclusion Criteria:

- Prior cardiac operations

- Severe left ventricular dysfunction with ejection fraction (EF) < 30%

- Patients with chest radiation

- Body mass index (BMI) > 35

- Severe peripheral vascular disease (PVD)

- Acute ischemia requiring emergent traditional coronary artery bypass graft (CABG)